Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29964853 | 0.90 | NAMPT (0.34) | NAMPTCHRNA7DRD2DRD3DPP4 | |
| SCHEMBL26983407 | 0.79 | ALDH1A1 (0.40) | HRH4 | |
| SCHEMBL26983467 | 0.77 | ALDH1A1 (0.35) | — | |
| SCHEMBL26983408 | 0.77 | DAO (0.33) | — | |
| SCHEMBL29965629 | 0.77 | HRH4 (0.30) | HRH4 | |
| SCHEMBL29964809 | 0.76 | RAB9A (0.43) | CHRNA7 | |
| SCHEMBL22398023 | 0.76 | LMNA (0.35) | HRH4FAAH | |
| SCHEMBL26983445 | 0.76 | LMNA (0.35) | HRH4FAAH | |
| SCHEMBL29965222 | 0.75 | — | — | |
| SCHEMBL27387742 | 0.75 | CYP2A6 (0.46) | NAMPTCHRNA7DRD2DRD3DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12600730-B2 | Substituted cyclopenta[c]pyrroles as ABHD6 antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 2026-04-14 | — | — | US | disclosed |
| US-20240270755-A1 | SUBSTITUTED CYCLOPENTA[c]PYRROLES AS ABHD6 ANTAGONISTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2024-08-15 | — | — | US | disclosed |
| EP-4317153-A1 | ABHD6 ANTAGONIST | ONO Pharmaceutical Co., Ltd. (JP) | 2024-02-07 | — | — | EP | disclosed |
| US-20240010658-A1 | ABHD6 ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 2024-01-11 | — | — | US | disclosed |
| WO-2022211060-A1 | ABHD6 ANTAGONIST | 小野薬品工業株式会社 | 2022-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240010658-A1 | ABHD6 ANTAGONIST | ABHD6, ABHD16A, ABHD12 | NAMPT 3379/4885CHRNA7 3068/4885DRD2 2593/4885 |
| US-20240270755-A1 | SUBSTITUTED CYCLOPENTA[c]PYRROLES AS ABHD6 ANTAGONISTS | ABHD6, ABHD16A, PITHD1 | NAMPT 3649/4885CHRNA7 4279/4885DRD2 2081/4885 |
| US-12600730-B2 | Substituted cyclopenta[c]pyrroles as ABHD6 antagonists | ABHD6, ABHD16A, HDHD5 | NAMPT 4726/4885CHRNA7 2909/4885DRD2 1933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.