Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902646 | 0.86 | IRAK4 (0.45) | ALDH1A1HTTMCL1KDM4EMAPT | |
| SCHEMBL29385278 | 0.83 | MCL1 (0.59) | ALDH1A1HTTMCL1SMN1; SMN2TSHR | |
| SCHEMBL5515234 | 0.83 | MCL1 (0.59) | ALDH1A1HTTMCL1SMN1; SMN2TSHR | |
| SCHEMBL8854263 | 0.83 | POLB (0.42) | ALDH1A1HTTMCL1SMN1; SMN2POLB | |
| SCHEMBL29941371 | 0.81 | KMT2A (0.47) | ALDH1A1HTTSMN1; SMN2KDM4ETSHR | |
| SCHEMBL6627930 | 0.79 | CA1 (0.65) | ALDH1A1HTTMCL1KDM4EMAPT | |
| SCHEMBL364343 | 0.79 | BCAT2 (0.56) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL6455529 | 0.78 | CA12 (0.45) | SMN1; SMN2MAPTCA1CA2CA9 | |
| SCHEMBL29451283 | 0.77 | ALDH1A1 (0.40) | ALDH1A1HTTMCL1SMN1; SMN2KDM4E | |
| SCHEMBL18584927 | 0.77 | ALDH1A1 (0.44) | ALDH1A1HTTMCL1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-04-06 | — | — | US | disclosed |
| EP-3746124-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2020-12-09 | — | — | EP | disclosed |
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |
| US-20100189685-A1 | Antiviral Drugs for Treatment or Prevention of Dengue Infection | SIGA TECHNOLOGIES, INC. | 2010-07-29 | — | — | US | disclosed |
| US-20090054469-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| US-20050037923-A1 | Herbicidal mixture based on 7-pyrazolybenzoxazoles | BASF AKTIENGESELLSCHAFT (DE) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100189685-A1 | Antiviral Drugs for Treatment or Prevention of Dengue Infection | EIF2AK2, HAVCR2, SNRPE | ALDH1A1 2072/4885HTT 3895/4885MCL1 4444/4885 |
| US-20230104936-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | ALDH1A1 3737/4885HTT 1696/4885MCL1 2415/4885 |
| US-20090054469-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | BRAF, RAF1, ARAF | ALDH1A1 629/4885HTT 4717/4885MCL1 77/4885 |
| US-20050037923-A1 | Herbicidal mixture based on 7-pyrazolybenzoxazoles | DDT, CYP2W1, CYP3A7 | ALDH1A1 291/4885HTT 3249/4885MCL1 3566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.