Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RGS12 | O14924 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 6/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004608 | 0.92 | PTGS2 (0.49) | PLA2G2APTGS2FAAHPLA2G1BDAGLA | |
| SCHEMBL1999688 | 0.86 | PTGDR2 (0.43) | MEN1RGS12ALDH1A1LMNACYP1A2 | |
| SCHEMBL2006022 | 0.82 | FAAH (0.41) | FAAHPTGDR2DAGLA | |
| SCHEMBL2005616 | 0.82 | ALDH1A1 (0.51) | MEN1RGS12ALDH1A1LMNACYP1A2 | |
| SCHEMBL3003472 | 0.82 | PTGS2 (0.61) | MEN1RGS12ALDH1A1LMNACYP1A2 | |
| SCHEMBL4380902 | 0.80 | PTGS2 (0.63) | MEN1LMNACYP1A2MAPTCYP2C9 | |
| SCHEMBL2000656 | 0.79 | PTGS2 (0.51) | MEN1ALDH1A1MAPTKMT2APLA2G2A | |
| SCHEMBL12628702 | 0.76 | LMNA (0.49) | ALDH1A1LMNAMAPTPLA2G2AFAAH | |
| SCHEMBL2011921 | 0.76 | LMNA (0.42) | ALDH1A1LMNAMAPTPKMFAAH | |
| SCHEMBL12628278 | 0.75 | PTGS2 (0.43) | PLA2G2APTGS2PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197708-A1 | INDOLE COMPOUNDS | IDO1, IDO2, TPH2 | MEN1 3970/4885RGS12 1030/4885ALDH1A1 1229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.