Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 10/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29123324 | 0.89 | LTA4H (0.54) | MAPK1MAPTSCN9ATHRBCDK2 | |
| SCHEMBL24664170 | 0.89 | LTA4H (0.54) | MAPK1MAPTSCN9ATHRBCDK2 | |
| SCHEMBL30005275 | 0.88 | LTA4H (0.52) | SCN9AFPR2LTA4HFFAR1 | |
| SCHEMBL29123473 | 0.83 | SCN9A (0.46) | MAPK1SCN9AFPR2LTA4HFFAR1 | |
| SCHEMBL29123469 | 0.83 | SCN9A (0.46) | MAPK1SCN9AFPR2LTA4HFFAR1 | |
| SCHEMBL27171432 | 0.82 | MAPK1 (0.49) | MAPK1MAPTSCN9ATHRBALDH1A1 | |
| SCHEMBL29123537 | 0.80 | MAPK1 (0.42) | MAPK1MAPTSCN9AFFAR1 | |
| SCHEMBL29123536 | 0.80 | MAPK1 (0.42) | MAPK1MAPTSCN9AFFAR1 | |
| SCHEMBL29123534 | 0.80 | MAPK1 (0.44) | MAPK1MAPTSCN9AFFAR1 | |
| SCHEMBL24664167 | 0.80 | MAPK1 (0.42) | MAPK1MAPTSCN9AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323062-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | Novartis AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |