Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.52 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10724375 | 0.73 | POLB (0.67) | SMN1; SMN2KMT2AMEN1DRD2DRD3 | |
| SCHEMBL29936294 | 0.70 | LPAR2 (1.00) | LPAR1LPAR2DRD3SIGMAR1 | |
| SCHEMBL26907286 | 0.70 | LPAR2 (1.00) | LPAR1LPAR2DRD3SIGMAR1 | |
| SCHEMBL29936087 | 0.68 | PKM (0.46) | LPAR1LPAR2LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL28794390 | 0.68 | ALDH1A1 (0.49) | MAPK1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL23794675 | 0.67 | NPC1 (0.50) | LMNASMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL9096579 | 0.67 | CA2 (0.46) | LMNASMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL17367677 | 0.66 | KDM4E (0.62) | KMT2AMEN1KDM4EDRD2DRD3 | |
| SCHEMBL10728118 | 0.66 | POLB (0.63) | LMNASMN1; SMN2KMT2AMEN1DRD2 | |
| SCHEMBL25072808 | 0.65 | POLB (0.50) | LMNASMN1; SMN2KMT2AKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4072670-A1 | QUINAZOLINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2022-10-19 | — | — | EP | claimed |