Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30945108 | 0.86 | NR1H2 (0.40) | MEN1KMT2APARP1HSD11B1GPR119 | |
| SCHEMBL2253695 | 0.85 | NR1H2 (0.44) | PARP1KDM4EGPR119CA1CA2 | |
| SCHEMBL30165832 | 0.81 | ALDH1A1 (0.50) | MAPTALDH1A1LMNAADRB1SIRT6 | |
| SCHEMBL30080495 | 0.76 | STS (0.49) | MAPTALDH1A1LMNAPARP1SMN1; SMN2 | |
| SCHEMBL31634907 | 0.76 | ALDH1A1 (0.52) | MAPTALDH1A1LMNAKMT2APARP1 | |
| SCHEMBL31437077 | 0.75 | ALDH1A1 (0.43) | MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL8147630 | 0.75 | MAPT (0.43) | MAPTALDH1A1LMNAPARP1KDM4E | |
| SCHEMBL4265890 | 0.74 | HTR6 (0.41) | ALDH1A1LMNAMEN1KMT2APARP1 | |
| SCHEMBL1871191 | 0.74 | ALDH1A1 (0.61) | MAPTALDH1A1LMNAKDM4EGPR119 | |
| SCHEMBL31257816 | 0.73 | ALDH1A1 (0.42) | MAPTALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115286617-B | PROTAC compound for targeted degradation of NAMPT and application thereof | 中国人民解放军海军军医大学 | 2024-04-30 | — | — | CN | disclosed |
| CN-115286617-A | Protac compound for targeted degradation of NAMPT and application thereof | 中国人民解放军海军军医大学 | 2022-11-04 | — | — | CN | disclosed |