Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976836 | 1.00 | TRPV4 (0.32) | TRPV4ULK1ENPP3ENPP1 | |
| SCHEMBL31523025 | 0.76 | MBOAT4 (0.34) | — | |
| SCHEMBL23976834 | 0.76 | MBOAT4 (0.32) | ULK1 | |
| SCHEMBL23832855 | 0.76 | ENPP3 (0.37) | ENPP3ENPP1 | |
| SCHEMBL29703394 | 0.69 | TRPV4 (0.42) | TRPV4 | |
| SCHEMBL17964092 | 0.69 | TRPV4 (0.42) | TRPV4 | |
| SCHEMBL2145810 | 0.67 | KDM5B (0.31) | — | |
| SCHEMBL19778533 | 0.67 | GRM4 (0.30) | — | |
| SCHEMBL29698226 | 0.67 | GRM4 (0.30) | — | |
| SCHEMBL27282962 | 0.67 | JUN (0.40) | ULK1ENPP3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143187-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-ALPHA AND THEIR METHODS OF USE | Novartis AG (CH) | 2023-03-08 | — | — | EP | disclosed |
| CN-115485275-A | Compounds and compositions that inhibit HIF 2-alpha activity and methods of use thereof | 诺华股份有限公司 | 2022-12-16 | — | — | CN | disclosed |