Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31425499 | 0.78 | ALDH1A1 (0.44) | ADORA1ADORA2APARP1NOS3NOS1 | |
| SCHEMBL9037765 | 0.69 | RXFP1 (0.50) | KDM4EADORA1ADORA2APDE4ACYP1A2 | |
| SCHEMBL18152241 | 0.69 | LDHA (0.58) | KDM4ETP53PARP1PDE4ACYP1A2 | |
| SCHEMBL11591420 | 0.67 | KDM4E (0.46) | KDM4ETP53ADORA1ADORA2APDE4A | |
| SCHEMBL31425543 | 0.67 | DYRK1A (0.39) | KDM4EADORA1ADORA2APDE4A | |
| SCHEMBL20323370 | 0.66 | KDM4E (0.36) | KDM4ETP53CYP1A2HPGDCYP2C19 | |
| SCHEMBL6639554 | 0.65 | MAT2A (0.46) | KDM4EADORA1ADORA2APARP1HPGD | |
| SCHEMBL1813535 | 0.65 | MEN1 (0.42) | KDM4ETP53CYP1A2CYP2C9HPGD | |
| SCHEMBL16943061 | 0.64 | MCHR1 (0.47) | — | |
| SCHEMBL12889714 | 0.63 | NOS3 (0.42) | KDM4ETP53ADORA1ADORA2ANOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253252-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS HPK1 INHIBITORS | SILEXON BIOTECH CO., LTD. (CN) | 2022-12-08 | — | — | WO | disclosed |