Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Resomelagon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Resomelagon SCHEMBL30065112 | 1.00 | RAB9A (0.39) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| Resomelagon SCHEMBL30010038 | 0.94 | RAB9A (0.41) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| Resomelagon SCHEMBL31103565 | 0.94 | RAB9A (0.41) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| Resomelagon SCHEMBL28929656 | 0.94 | RAB9A (0.41) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| Resomelagon SCHEMBL30084719 | 0.93 | MAPT (0.41) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| Resomelagon SCHEMBL30064272 | 0.92 | NPC1 (0.38) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| Resomelagon SCHEMBL30853069 | 0.91 | MAPT (0.40) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| Resomelagon SCHEMBL30853077 | 0.90 | NPC1 (0.42) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| Resomelagon SCHEMBL31103411 | 0.90 | ALDH1A1 (0.46) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| Resomelagon SCHEMBL30853078 | 0.90 | NPC1 (0.42) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4684835-A2 | PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS | SynAct Pharma ApS (DK) | 2026-01-28 | — | — | EP | claimed |
| EP-4359076-A1 | PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS | SynAct Pharma ApS (DK) | 2024-05-01 | — | — | EP | claimed |
| CN-117642382-A | Phenylpyrrole aminoguanidine salts and formulations | 西奈克制药有限公司 | 2024-03-01 | — | — | CN | claimed |
| WO-2022268825-A1 | PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS | SYNACT PHARMA APS (DK) | 2022-12-29 | — | — | WO | claimed |
| EP-4684835-A2 | PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS | SynAct Pharma ApS (DK) | 2026-01-28 | — | — | EP | disclosed |
| WO-2025124760-A1 | TREATMENT OF SUBPOPULATION OF PATIENTS WITH RHEUMATOID ARTHRITIS | SYNACT PHARMA APS (DK) | 2025-06-19 | — | — | WO | disclosed |
| US-12239631-B2 | Polymorphs of phenyl pyrrole aminoguandium salts | SYNACT PHARMA APS (DK) | 2025-03-04 | — | — | US | disclosed |
| US-20250032449-A1 | TREATMENT OF RHEUMATOID ARTHRITIS | SYNACT PHARMA APS (DK) | 2025-01-30 | — | — | US | disclosed |
| US-20240335423-A1 | POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS | SYNACT PHARMA APS (DK) | 2024-10-10 | — | — | US | disclosed |
| EP-4440572-A1 | TREATMENT OF RHEUMATOID ARTHRITIS | SynAct Pharma ApS (DK) | 2024-10-09 | — | — | EP | disclosed |
| CN-118613260-A | Treatment of rheumatoid arthritis | 西奈克制药有限公司 | 2024-09-06 | — | — | CN | disclosed |
| EP-4359383-A1 | SALTS OF PHENYL PYRROLE AMINOGUANIDINE AND POLYMORPHS OF PHENYL PYRROLE AMINOGUANIDINIUM SALTS | SynAct Pharma ApS (DK) | 2024-05-01 | — | — | EP | disclosed |
| CN-117836271-A | Salts of phenylpyrrolaminoguanidine and polymorphs of phenylpyrrolaminoguanidine onium salts | 西奈克制药有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-117642382-A | Phenylpyrrole aminoguanidine salts and formulations | 西奈克制药有限公司 | 2024-03-01 | — | — | CN | disclosed |
| US-20230271922-A9 | POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS | SYNACT PHARMA APS (DK) | 2023-08-31 | — | — | US | disclosed |
| WO-2023094692-A1 | TREATMENT OF RHEUMATOID ARTHRITIS | SYNACT PHARMA APS (DK) | 2023-06-01 | — | — | WO | disclosed |
| US-20230114865-A1 | PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS | SYNACT PHARMA APS (DK) | 2023-04-13 | — | — | US | disclosed |
| US-20230002319-A1 | POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS | SYNACT PHARMA APS (DK) | 2023-01-05 | — | — | US | disclosed |
| WO-2022268825-A1 | PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS | SYNACT PHARMA APS (DK) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022268814-A1 | SALTS OF PHENYL PYRROLE AMINOGUANIDINE AND POLYMORPHS OF PHENYL PYRROLE AMINOGUANIDINIUM SALTS | SYNACT PHARMA APS (DK) | 2022-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250032449-A1 | TREATMENT OF RHEUMATOID ARTHRITIS | MTX1, MTX2, SYVN1 | RAB9A 2233/4885NPC1 4061/4885ALDH1A1 988/4885 |
| US-20230114865-A1 | PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS | AAAS, PGC, DNPEP | RAB9A 33/4885NPC1 3607/4885ALDH1A1 3598/4885 |
| US-20230271922-A9 | POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS | HLA-C, HLA-DRB1, HLA-B | RAB9A 1658/4885NPC1 2537/4885ALDH1A1 2425/4885 |
| US-12239631-B2 | Polymorphs of phenyl pyrrole aminoguandium salts | HLA-C, HLA-DRB1, HLA-B | RAB9A 1658/4885NPC1 2537/4885ALDH1A1 2425/4885 |
| US-20230002319-A1 | POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS | HLA-C, HLA-DRB1, HLA-B | RAB9A 1658/4885NPC1 2537/4885ALDH1A1 2425/4885 |
| US-20240335423-A1 | POLYMORPHS OF PHENYL PYRROLE AMINOGUANDIUM SALTS | HLA-C, HLA-DRB1, HLA-B | RAB9A 1658/4885NPC1 2537/4885ALDH1A1 2425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.