Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Abietic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.80 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.80 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.80 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.80 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.80 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.80 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Abietic Acid SCHEMBL324776 | 1.00 | HSD17B10 (0.80) | HSD17B10ALOX15LMNAPDK1PDK2 | |
| Abietic Acid SCHEMBL324775 | 1.00 | HSD17B10 (0.80) | HSD17B10ALOX15LMNAPDK1PDK2 | |
| Abietic Acid SCHEMBL8335225 | 0.99 | HSD17B10 (0.81) | HSD17B10ALOX15LMNAPDK1PDK2 | |
| Abietic Acid SCHEMBL30176404 | 0.99 | HSD17B10 (0.81) | HSD17B10ALOX15LMNAPDK1PDK2 | |
| Abietic Acid SCHEMBL8335223 | 0.99 | HSD17B10 (0.81) | HSD17B10ALOX15LMNAPDK1PDK2 | |
| Abietic Acid SCHEMBL600776 | 0.98 | HSD17B10 (0.80) | HSD17B10ALOX15LMNAPDK1PDK2 | |
| Abietic Acid SCHEMBL5711211 | 0.98 | PDK1 (0.83) | HSD17B10ALOX15LMNAPDK1PDK2 | |
| Abietic Acid SCHEMBL10524200 | 0.98 | HSD17B10 (0.80) | HSD17B10ALOX15LMNAPDK1PDK2 | |
| Abietic Acid SCHEMBL16401716 | 0.98 | HSD17B10 (0.80) | HSD17B10ALOX15LMNAPDK1PDK2 | |
| Abietic Acid SCHEMBL152817 | 0.98 | HSD17B10 (0.80) | HSD17B10ALOX15LMNAPDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948505-B1 | THERMOPLASTIC COMPOSITIONS CONTAINING NANOSCALE-SIZED PARTICLE ADDITIVES FOR LASER DIRECT STRUCTURING AND METHODS FOR THE MANUFACTURE AND USE THEREOF | SHPP GLOBAL TECH BV (NL) | 2022-11-16 | — | — | EP | disclosed |