Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925398 | 0.76 | L3MBTL1 (0.44) | PIK3CAHPGDSKDRKDM4EALDH1A1 | |
| SCHEMBL20552273 | 0.76 | GRM5 (0.56) | KDRALDH1A1CYP3A4CDK8 | |
| SCHEMBL31527594 | 0.76 | KEAP1 (0.49) | HPGDSKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL21771077 | 0.74 | HPGDS (0.47) | HPGDSKDM4EALDH1A1HPGDCDK8 | |
| SCHEMBL20553716 | 0.73 | HPGDS (0.52) | HPGDS | |
| SCHEMBL594405 | 0.73 | AHR (0.50) | KDRAHRPDPK1REN | |
| SCHEMBL30065768 | 0.73 | XDH (0.48) | XDHSLC22A12KDM4EALDH1A1CYP3A4 | |
| SCHEMBL23164297 | 0.72 | CDK1 (0.40) | CDK1KDRKDM4ECYP3A4 | |
| SCHEMBL4192415 | 0.71 | XDH (0.59) | XDHSLC22A12ALDH1A1HSD17B10CHRNB4 | |
| SCHEMBL20552457 | 0.71 | TRPV1 (0.50) | HPGDSCDK8SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12351556-B2 | Pyridin-2(1H)one derivatives, their preparation and their use for the treatment of pain | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2025-07-08 | — | — | US | disclosed |
| US-20220363643-A1 | NOVEL PYRIDIN-2(1H)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF PAIN | CENTRE HOSPITALIER UNIVERSITAIRE DE CLERMONT-FD (FR) | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363643-A1 | NOVEL PYRIDIN-2(1H)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF PAIN | P2RX3, OPRL1, P2RX6 | XDH 1051/4885SLC22A12 3909/4885PIK3CA 3237/4885 |
| US-12351556-B2 | Pyridin-2(1H)one derivatives, their preparation and their use for the treatment of pain | P2RX3, P2RX6, P2RX4 | XDH 938/4885SLC22A12 3755/4885PIK3CA 3113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.