Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL17866113 | 0.69 | — | — | |
| Formic Acid Methyl Ester SCHEMBL28856773 | 0.67 | CA4 (0.39) | — | |
| Oxalic Acid SCHEMBL30342508 | 0.67 | CA4 (0.44) | — | |
| SCHEMBL979853 | 0.65 | — | — | |
| SCHEMBL7628702 | 0.65 | — | — | |
| SCHEMBL22423568 | 0.65 | — | — | |
| Oxalic Acid SCHEMBL1088069 | 0.64 | CA4 (0.78) | — | |
| SCHEMBL15522958 | 0.62 | — | — | |
| Bicarbonate SCHEMBL7791293 | 0.62 | CA4 (0.46) | — | |
| Potassium Ion SCHEMBL80042 | 0.62 | CA4 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107820494-A | Nuclear receptor modulators | 艾伯维公司 | 2018-03-20 | — | — | CN | disclosed |
| CN-107335061-A | Cytotoxic benzodiazepine * derivatives | 伊缪诺金公司 | 2017-11-10 | — | — | CN | disclosed |
| CN-103687623-B | Cytotoxic benzodiazepine derivatives | 伊缪诺金公司 | 2017-06-09 | — | — | CN | disclosed |
| US-9162991-B2 | Cinnamoyl inhibitors of transglutaminase | UNIVERSITY OF OTTAWA (CA) | 2015-10-20 | — | — | US | disclosed |
| US-20140024837-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | UNIVERSITE DE MONTREAL (CA) | 2014-01-23 | — | — | US | disclosed |
| US-8614233-B2 | Cinnamoyl inhibitors of transglutaminase | UNIVERSITE DE MONTREAL (CA) | 2013-12-24 | — | — | US | disclosed |
| US-20100204280-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | UNIVERSITE DE MONTREAL (CA) | 2010-08-12 | — | — | US | disclosed |
| WO-2008144933-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | Université de Montréal (CA) | 2008-12-04 | — | — | WO | disclosed |