Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.63 |
| ▸ | DHODH | Q02127 | 4/20 | 0.60 |
| ▸ | TACR3 | P29371 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13957934 | 1.00 | KDM4E (0.63) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL30604083 | 0.89 | TACR3 (0.57) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL30604241 | 0.85 | TACR3 (0.66) | KDM4ELMNASMN1; SMN2DHODHTACR3 | |
| SCHEMBL29359819 | 0.82 | KDM4E (0.83) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL18746 | 0.82 | KDM4E (0.83) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL30595092 | 0.81 | KDM4E (0.80) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL374558 | 0.81 | KDM4E (0.80) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL374556 | 0.81 | KDM4E (0.80) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| Potassium SCHEMBL93448 | 0.81 | KDM4E (0.80) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL7962360 | 0.81 | KDM4E (0.80) | KDM4ELMNASMN1; SMN2PDE10ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074880-A1 | NOVEL QUINOLINE DERIVATIVES AND USES THEREOF | ST EUROPEO DI ONCOLOGIA S R L (IT) | 2025-03-06 | — | — | US | disclosed |
| EP-4337640-A1 | NOVEL QUINOLINE DERIVATIVES AND USES THEREOF | Istituto Europeo di Oncologia S.r.l. (IT) | 2024-03-20 | — | — | EP | disclosed |
| CN-116745291-A | N- (2- (4-cyanothiazolidin-3-yl) -2-oxoethyl) -quinoline-4-carboxamide | 阿斯利康(瑞典)有限公司 | 2023-09-12 | — | — | CN | disclosed |
| WO-2022238863-A1 | NOVEL QUINOLINE DERIVATIVES AND USES THEREOF | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2022-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250074880-A1 | NOVEL QUINOLINE DERIVATIVES AND USES THEREOF | NDC1, CHD1L, NUMA1 | KDM4E 951/4885LMNA 907/4885SMN1; SMN2 2932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.