SCHEMBL30104876

SCHEMBL30104876

CCCCOC1OC(=O)C(Br)=C1SCc1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSB P07858 2/20 0.36
ALDH1A1 P00352 6/20 0.35
TSHR P16473 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
CYP3A4 P08684 1/20 0.35
MAPK1 P28482 1/20 0.35
NT5E P21589 2/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
S100A4 P26447 1/20 0.33
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32
CA6 P23280 1/20 0.32
CA5A P35218 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30104840 0.87 NR2E3 (0.37) CTSBALDH1A1MAPK1S100A4NR2E3
SCHEMBL30104893 0.83 CCKBR (0.41) CTSBALDH1A1L3MBTL1S100A4SMN1; SMN2
SCHEMBL30104902 0.82 S100A4 (0.37) CTSBALDH1A1L3MBTL1MAPK1S100A4
SCHEMBL30104903 0.80 KDM4E (0.33) ALDH1A1NT5EMAPTKDM4E
SCHEMBL30104872 0.79 POLB (0.38) ALDH1A1S100A4HPGDSMN1; SMN2KMT2A
SCHEMBL30104905 0.73 NPSR1 (0.37) CTSBALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL29822002 0.72 KDM4E (0.35) ALDH1A1TSHRTDP1L3MBTL1NT5E
SCHEMBL30104867 0.72 MAPK1 (0.47) CTSBALDH1A1MAPK1CYP2C9CYP2C19
SCHEMBL30104826 0.68 G6PD (0.32) ALDH1A1TSHRS100A4KDM4E
SCHEMBL30104878 0.65 NUAK1 (0.33) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115583927-B Thioether compound, and preparation method and application thereof 华南师范大学 2024-07-12 CN disclosed
CN-115583927-A Thioether compound and preparation method and application thereof 华南师范大学 2023-01-10 CN disclosed