Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963640 | 0.83 | ROCK2 (0.49) | ADORA2AFYN | |
| SCHEMBL1900222 | 0.77 | CYP1A1 (0.53) | ADORA2AADORA1NPC1 | |
| SCHEMBL7655542 | 0.77 | CYP17A1 (0.45) | ADORA2AADORA1NPC1MAP3K11CYP3A4 | |
| SCHEMBL14274543 | 0.76 | ADORA1 (0.51) | ADORA2AADORA1LRRK2 | |
| SCHEMBL20162678 | 0.72 | PDGFRB (0.45) | NPC1CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL7019753 | 0.71 | ABCG2 (0.39) | ADORA2AADORA1 | |
| SCHEMBL10213928 | 0.71 | JAK2 (0.61) | NPC1MAP3K11CYP3A4CYP2D6CA12 | |
| SCHEMBL5850255 | 0.71 | NPC1 (0.79) | NPC1MAP3K11CA12CA1CA2 | |
| SCHEMBL16497095 | 0.70 | NUDT1 (0.43) | ADORA2AADORA1LRRK2 | |
| SCHEMBL18828552 | 0.69 | NPC1 (0.59) | ADORA2AADORA1NPC1MAP3K11CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11547704-B2 | Chemical compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11547704-B2 | Chemical compounds | ATF4, XBP1, EIF2B5 | ADORA2A 2289/4885ADORA1 2202/4885NPC1 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.