Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380436 | 0.94 | NR1H2 (0.45) | LMNANR1H2KAT6AMAPTPGR | |
| SCHEMBL3378995 | 0.92 | LMNA (0.51) | LMNANR1H2KAT6AMAPTPGR | |
| SCHEMBL302950 | 0.85 | NR3C1 (0.55) | LMNAMAPTPGRNR3C1TP53 | |
| SCHEMBL3377911 | 0.83 | MAPT (0.54) | MAPTNR3C1MEN1KMT2ARORC | |
| SCHEMBL303335 | 0.80 | NR1H2 (0.45) | NR1H2KAT6AMEN1KMT2ARORC | |
| SCHEMBL2213543 | 0.80 | ALDH1A1 (0.40) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3380874 | 0.79 | NR3C1 (0.54) | MAPTNR3C1MEN1KMT2ATP53 | |
| SCHEMBL3376406 | 0.79 | SIRT2 (0.44) | NR1H2KAT6ANR3C1MEN1KMT2A | |
| SCHEMBL303674 | 0.78 | SIRT2 (0.44) | NR1H2KAT6AMEN1KMT2ARORC | |
| SCHEMBL303336 | 0.77 | NR1H2 (0.45) | NR1H2MEN1KMT2ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |