Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231625 | 0.86 | MAP1LC3B (0.74) | MAP1LC3BMAPTALDH1A1HPGDCA9 | |
| SCHEMBL29115369 | 0.86 | MAP1LC3B (0.74) | MAP1LC3BMAPTALDH1A1HPGDCA9 | |
| SCHEMBL30677928 | 0.86 | MAP1LC3B (0.74) | MAP1LC3BMAPTALDH1A1HPGDCA9 | |
| SCHEMBL30228362 | 0.81 | ALDH1A1 (0.75) | MAP1LC3BMAPTALDH1A1HPGDCA9 | |
| SCHEMBL30228405 | 0.77 | CA9 (0.56) | MAP1LC3BMAPTALDH1A1HPGDCA9 | |
| SCHEMBL11215292 | 0.77 | ALDH1A1 (0.79) | MAP1LC3BMAPTALDH1A1HPGDCA9 | |
| SCHEMBL30231670 | 0.76 | ALDH1A1 (0.57) | MAPTALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL30231669 | 0.76 | ALDH1A1 (0.57) | MAPTALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL21648244 | 0.75 | CA12 (0.74) | ALDH1A1HPGDCA9CASP1CASP7 | |
| SCHEMBL8580581 | 0.75 | MAP1LC3B (0.80) | MAP1LC3BMAPTALDH1A1HPGDCA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |