Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19885961 | 0.78 | KDM4E (0.60) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL4539725 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL1144832 | 0.75 | KDM4E (0.65) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL4369016 | 0.75 | PLA2G4A (0.67) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL4816031 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL10762275 | 0.74 | PLA2G4B (0.43) | ALDH1A1MAPK14 | |
| SCHEMBL10762271 | 0.74 | PLA2G4B (0.43) | ALDH1A1MAPK14 | |
| SCHEMBL3033147 | 0.73 | KDM4E (0.67) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL5016941 | 0.73 | HRH3 (0.56) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL4360657 | 0.73 | PLA2G4A (0.68) | KDM4EALDH1A1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | KDM4E 1070/4885ALDH1A1 348/4885CYP1A2 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.