Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.39 |
| ▸ | CCR2 | P41597 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3024792 | 0.83 | ROCK2 (0.51) | ROCK2CCR2ROCK1DPP4HDAC8 | |
| SCHEMBL5148134 | 0.83 | ROCK2 (0.51) | ROCK2CCR2ROCK1DPP4HDAC8 | |
| SCHEMBL5027678 | 0.82 | CYP2D6 (0.41) | ROCK2CCR2ROCK1DPP4SCN8A | |
| SCHEMBL3033895 | 0.82 | CYP2D6 (0.41) | ROCK2CCR2ROCK1DPP4SCN8A | |
| SCHEMBL3032958 | 0.81 | ALDH1A1 (0.40) | ROCK2CCR2ROCK1DPP4SCN8A | |
| SCHEMBL5140554 | 0.81 | ROCK2 (0.50) | ROCK2CCR2ROCK1ACHE | |
| SCHEMBL5031248 | 0.76 | PGR (0.44) | ROCK2CCR2ROCK1DPP4HDAC8 | |
| SCHEMBL3024142 | 0.76 | PGR (0.51) | DPP4HDAC8HDAC6POLB | |
| SCHEMBL3029883 | 0.75 | PGR (0.53) | ROCK2CCR2ROCK1DPP4HDAC8 | |
| SCHEMBL3031592 | 0.74 | PGR (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216813-A1 | PYRROLIDINEANILINES | SMITHKLINE BEECHAM CORPORATION | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216813-A1 | PYRROLIDINEANILINES | PGF, ARG1, CYP19A1 | ROCK2 376/4885CCR2 838/4885ROCK1 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.