Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10415391 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 | |
| SCHEMBL968034 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 | |
| SCHEMBL21219167 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 | |
| SCHEMBL21219181 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 | |
| SCHEMBL21219179 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 | |
| SCHEMBL21219171 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 | |
| SCHEMBL21519878 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 | |
| SCHEMBL21219173 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 | |
| SCHEMBL21219169 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 | |
| SCHEMBL9577856 | 0.95 | CYP3A4 (0.39) | CYP3A4TSHRNFKB1NPSR1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500848-A | — | — | 2012-01-12 | — | — | JP | claimed |
| US-8044214-B2 | Process for preparing isoxazole compounds | ANGUS CHEMICAL COMPANY (US) | 2011-10-25 | — | — | US | claimed |
| EP-2318381-A1 | PROCESS FOR PREPARING ISOXAZOLE COMPOUNDS | Dow Global Technologies LLC (US) | 2011-05-11 | — | — | EP | claimed |
| WO-2010025035-A1 | PROCESS FOR PREPARING ISOXAZOLE COMPOUNDS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-03-04 | — | — | WO | claimed |
| US-20100048910-A1 | PROCESS FOR PREPARING ISOXAZOLE COMPOUNDS | ANGUS CHEMICAL COMPANY | 2010-02-25 | — | — | US | claimed |
| EP-2599840-B1 | SILVER INK COMPOSITION AND BASE MATERIAL | TOPPAN FORMS CO LTD (JP) | 2018-07-25 | — | — | EP | disclosed |
| US-9328254-B2 | Silver ink composition and substrate | TOPPAN FORMS CO., LTD. (JP) | 2016-05-03 | — | — | US | disclosed |
| EP-2599840-A1 | SILVER INK COMPOSITION AND BASE MATERIAL | Toppan Forms Co., Ltd. (JP) | 2013-06-05 | — | — | EP | disclosed |
| US-20130121872-A1 | Silver Ink Composition and Substrate | TOPPAN FORMS CO., LTD. (JP) | 2013-05-16 | — | — | US | disclosed |
| US-8044214-B2 | Process for preparing isoxazole compounds | ANGUS CHEMICAL COMPANY (US) | 2011-10-25 | — | — | US | disclosed |
| EP-2318381-A1 | PROCESS FOR PREPARING ISOXAZOLE COMPOUNDS | Dow Global Technologies LLC (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010025035-A1 | PROCESS FOR PREPARING ISOXAZOLE COMPOUNDS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-03-04 | — | — | WO | disclosed |
| US-20100048910-A1 | PROCESS FOR PREPARING ISOXAZOLE COMPOUNDS | ANGUS CHEMICAL COMPANY | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048910-A1 | PROCESS FOR PREPARING ISOXAZOLE COMPOUNDS | CYP11B2, CYP11B1, CYP3A7 | CYP3A4 12/4885TSHR 3112/4885NFKB1 851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.