SCHEMBL3026575

SCHEMBL3026575

Cc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.70
NPC1 O15118 5/20 0.70
ALDH1A1 P00352 4/20 0.68
SMN1; SMN2 Q16637 5/20 0.68
L3MBTL1 Q9Y468 1/20 0.68
MEN1 O00255 6/20 0.67
KMT2A Q03164 6/20 0.67
HTT P42858 4/20 0.67
MAPT P10636 4/20 0.67
LMNA P02545 3/20 0.67
NLRP1 Q9C000 1/20 0.67
CNR1 P21554 2/20 0.66
CYP3A4 P08684 1/20 0.66
RECQL P46063 1/20 0.64
NLRP3 Q96P20 2/20 0.61
EPHX1 P07099 1/20 0.61
ADORA3 P0DMS8 1/20 0.61
CHRM1 P11229 1/20 0.61
SLC6A2 P23975 1/20 0.61
PDE4A P27815 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1275920 0.89 ALDH1A1 (0.70) RAB9ANPC1ALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL4741253 0.89 MEN1 (0.76) RAB9ANPC1ALDH1A1SMN1; SMN2MEN1
SCHEMBL11048619 0.89 MEN1 (0.76) RAB9ANPC1ALDH1A1SMN1; SMN2MEN1
SCHEMBL4548043 0.83 SMN1; SMN2 (0.74) RAB9ANPC1ALDH1A1SMN1; SMN2MEN1
SCHEMBL13556605 0.83 RAB9A (0.65) RAB9ANPC1ALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL4548128 0.83 RAB9A (0.69) RAB9ANPC1ALDH1A1SMN1; SMN2MEN1
SCHEMBL13556601 0.83 MAPT (0.61) RAB9ANPC1ALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL493839 0.82 RAB9A (0.81) RAB9ANPC1ALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL10192061 0.82 RAB9A (0.81) RAB9ANPC1ALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL22103910 0.82 CNR1 (0.83) RAB9ANPC1ALDH1A1SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090239841-A1 Diaryl Ureas as CB1 Antagonists NEUROGEN CORPORATION 2009-09-24 US claimed
EP-1804785-A2 DIARYL UREAS AS CB1 ANTAGONISTS NEUROGEN CORPORATION (US) 2007-07-11 EP claimed
WO-2006049941-A2 DIARYL UREAS AS CB1 ANTAGONISTS NEUROGEN CORPORATION (US) 2006-05-11 WO claimed
EP-0382411-B1 Delivery of cytotoxic agents LILLY CO ELI (US) 1994-12-07 EP claimed
US-20240409504-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER DUKE UNIVERSITY 2024-12-12 US disclosed
US-20240317727-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER DUKE UNIVERSITY 2024-09-26 US disclosed
US-12098117-B2 Compositions and methods for the treatment of cancer DUKE UNIVERSITY (US) 2024-09-24 US disclosed
CN-113271941-B Urea derivatives for the treatment and/or prophylaxis of cancer 法国国家科学研究中心 2024-09-20 CN disclosed
US-20230157996-A1 SMALL-MOLECULE INHIBITOR TARGETING EB VIRUS NUCLEAR ANTIGEN PROTEIN, PREPARATION METHOD AND USE THEREOF Shenzhen Bay Laboratory (CN) 2023-05-25 US disclosed
US-20230157996-A1 SMALL-MOLECULE INHIBITOR TARGETING EB VIRUS NUCLEAR ANTIGEN PROTEIN, PREPARATION METHOD AND USE THEREOF Shenzhen Bay Laboratory (CN) 2023-05-25 US disclosed
US-20220106265-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER DUKE UNIVERSITY (US) 2022-04-07 US disclosed
US-20210380547-A1 UREA DERIVATIVES FOR TREATING AND/OR PREVENTING CANCER CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2021-12-09 US disclosed
WO-2020079184-A2 UREA DERIVATIVES FOR TREATING AND/OR PREVENTING CANCER CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2020-04-23 WO disclosed
WO-2017214505-A1 CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2017-12-14 WO disclosed
US-20100216871-A1 USE OF COMPOUNDS HAVING CCR ANTAGONISM TSUCHIMORI NOBORU 2010-08-26 US disclosed
US-20090239841-A1 Diaryl Ureas as CB1 Antagonists NEUROGEN CORPORATION 2009-09-24 US disclosed
US-20090239841-A1 Diaryl Ureas as CB1 Antagonists NEUROGEN CORPORATION 2009-09-24 US disclosed
US-20090239841-A1 Diaryl Ureas as CB1 Antagonists NEUROGEN CORPORATION 2009-09-24 US disclosed
US-20050245537-A1 Use of compounds having ccr antagonism TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-11-03 US disclosed
US-4444863-A UREA COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1984-04-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240409504-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER HSF1, HSP90AB1, HSP90AA1 RAB9A 3091/4885NPC1 1296/4885ALDH1A1 2667/4885
US-20230157996-A1 SMALL-MOLECULE INHIBITOR TARGETING EB VIRUS NUCLEAR ANTIGEN PROTEIN, PREPARATION METHOD AND USE THEREOF SSB, EBNA1BP2, PML RAB9A 1810/4885NPC1 1422/4885ALDH1A1 4846/4885
US-20090239841-A1 Diaryl Ureas as CB1 Antagonists CNR1, CNR2, OPRL1 RAB9A 815/4885NPC1 927/4885ALDH1A1 994/4885
US-20210380547-A1 UREA DERIVATIVES FOR TREATING AND/OR PREVENTING CANCER CXCR1, CXCR2, CXCR6 RAB9A 1386/4885NPC1 331/4885ALDH1A1 639/4885
US-20050245537-A1 Use of compounds having ccr antagonism CCR1, CCR3, CCR2 RAB9A 2178/4885NPC1 1090/4885ALDH1A1 1272/4885
US-20100216871-A1 USE OF COMPOUNDS HAVING CCR ANTAGONISM CCR1, CCR3, CCR2 RAB9A 2178/4885NPC1 1090/4885ALDH1A1 1272/4885
US-12098117-B2 Compositions and methods for the treatment of cancer HSF1, HSP90AB1, HSP90AA1 RAB9A 3091/4885NPC1 1296/4885ALDH1A1 2667/4885
US-20240317727-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER HSF1, HSP90AB1, HSP90AA1 RAB9A 3091/4885NPC1 1296/4885ALDH1A1 2667/4885
US-20220106265-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER HSF1, HSP90AB1, HSP90AA1 RAB9A 3091/4885NPC1 1296/4885ALDH1A1 2667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.