Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APOL1 | O14791 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30280535 | 0.79 | PKM (0.58) | PKMP2RX7MAPTMAOBALDH1A1 | |
| SCHEMBL30280664 | 0.78 | PKM (0.41) | PKMP2RX7MEN1KMT2ATDP1 | |
| SCHEMBL10574366 | 0.75 | IDO1 (0.39) | PKMP2RX7MAPTMAOBALDH1A1 | |
| SCHEMBL23977073 | 0.74 | EED (0.36) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL25352654 | 0.74 | MEN1 (0.36) | PKMMEN1KMT2ATDP1RAB9A | |
| SCHEMBL500057 | 0.72 | IDO1 (0.37) | PKMP2RX7MAOB | |
| SCHEMBL1707104 | 0.72 | RIPK1 (0.46) | P2RX7TDP1MAOBRIPK1ALDH1A1 | |
| SCHEMBL19859281 | 0.71 | IDO1 (0.41) | PKMP2RX7MEN1KMT2ATDP1 | |
| SCHEMBL30883124 | 0.71 | P2RX7 (0.45) | PKMP2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL909006 | 0.71 | P2RX7 (0.45) | PKMP2RX7MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4404935-A1 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | Merck Sharp & Dohme LLC (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049060-A1 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME LLC (US) | 2023-03-30 | — | — | WO | disclosed |