Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 12/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 12/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30289054 | 0.78 | GABRA1 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL30939011 | 0.71 | MAOB (0.54) | PGRLMNAMAOB | |
| SCHEMBL24607774 | 0.70 | PGR (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL29751413 | 0.70 | PGR (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL12207033 | 0.70 | PSMB8 (0.49) | PGRLMNAMAOB | |
| SCHEMBL29996454 | 0.69 | PGR (0.61) | GABRG2GABRB3GABRA3GABRA5PGR | |
| SCHEMBL30288955 | 0.69 | NAMPT (0.49) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL12056344 | 0.67 | LMNA (0.53) | PGRLMNAMAOBCDK2AKT1 | |
| SCHEMBL13105640 | 0.67 | GABRG2 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL163615 | 0.67 | GABRG2 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |