Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12207029 | 0.83 | ACSS2 (0.41) | PSMB8CA12CA1CA9LEF1 | |
| SCHEMBL13015583 | 0.82 | ADORA3 (0.51) | PSMB8BRD4LRRK2LMNAADORA3 | |
| SCHEMBL30896791 | 0.81 | ACSS2 (0.42) | PSMB8CA12CA1CA9LEF1 | |
| SCHEMBL21635682 | 0.79 | ALDH1A1 (0.41) | CA12CA1CA9LMNAPGR | |
| SCHEMBL30289054 | 0.77 | GABRA1 (0.50) | BRD4LMNAPGRB3GNT2ALDH1A1 | |
| SCHEMBL20529237 | 0.76 | KDM4E (0.55) | LMNAALDH1A1GAA | |
| SCHEMBL27056782 | 0.76 | PSMB8 (0.51) | PSMB8BRD4LRRK2LMNAPGR | |
| SCHEMBL11548746 | 0.76 | PSMB8 (0.54) | PSMB8BRD4LRRK2CA12CA9 | |
| SCHEMBL30763590 | 0.76 | ACHE (0.36) | PSMB8CA12CA1CA9LEF1 | |
| SCHEMBL12361997 | 0.74 | LMNA (0.53) | PSMB8BRD4LRRK2LMNAADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497307-B2 | Aryl guanidine F1F0-ATPase inhibitors and related methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497307-B2 | Aryl guanidine F1F0-ATPase inhibitors and related methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-07-30 | — | — | US | disclosed |
| US-20110251200-A1 | ARYL GUANIDINE F1F0-ATPASE INHIBITORS AND RELATED METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251200-A1 | ARYL GUANIDINE F1F0-ATPASE INHIBITORS AND RELATED METHODS | ATP5F1A, ATP5F1D, ATP5F1B | PSMB8 2857/4885BRD4 1176/4885LRRK2 2240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.