Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 3/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30296495 | 0.80 | NPC1 (0.36) | EPAS1NPC1ALDH1A1LMNATP53 | |
| SCHEMBL30296178 | 0.79 | PTPN11 (0.42) | TDO2NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL30296624 | 0.79 | BACE1 (0.33) | BACE1AHRPTGS1PTGS2 | |
| SCHEMBL30296723 | 0.79 | NPC1 (0.31) | NPC1ALDH1A1LMNATP53MAPT | |
| SCHEMBL31026731 | 0.78 | TDO2 (0.40) | TDO2FABP4FABP3FABP5ENPP2 | |
| SCHEMBL26092700 | 0.78 | TDO2 (0.40) | TDO2FABP4FABP3FABP5ENPP2 | |
| SCHEMBL31026738 | 0.77 | FABP4 (0.42) | TDO2FABP4ENPP2RIPK2PIK3CA | |
| SCHEMBL30296520 | 0.77 | EPAS1 (0.39) | EPAS1NPC1ALDH1A1LMNATP53 | |
| SCHEMBL26095265 | 0.77 | FABP4 (0.42) | TDO2FABP4ENPP2RIPK2PIK3CA | |
| SCHEMBL30296548 | 0.76 | NPC1 (0.34) | EPAS1NPC1ALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260070909-A1 | GPR65 MODULATORS | PATHIOS THERAPEUTICS LTD (GB) | 2026-03-12 | — | — | US | disclosed |
| EP-4665453-A1 | GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2025-12-24 | — | — | EP | disclosed |
| EP-4536661-A1 | GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2025-04-16 | — | — | EP | disclosed |
| US-20240368173-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-11-07 | — | — | US | disclosed |
| EP-4419203-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| WO-2024170880-A1 | GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-08-22 | — | — | WO | disclosed |
| CN-118451080-A | Tricyclic GPR65 modulators | 帕蒂奥斯治疗有限公司 | 2024-08-06 | — | — | CN | disclosed |
| WO-2023242537-A1 | GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2023-12-21 | — | — | WO | disclosed |
| WO-2023067322-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2023-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368173-A1 | TRICYCLIC GPR65 MODULATORS | GPR65, GPR3, NR1H2 | TDO2 2047/4885FABP4 1409/4885FABP3 663/4885 |
| US-20260070909-A1 | GPR65 MODULATORS | GPR65, GPR68, GPR84 | TDO2 2975/4885FABP4 1246/4885FABP3 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.