Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30090486 | 0.90 | KCNH2 (0.39) | ALDH1A1L3MBTL1AXLFLT3 | |
| SCHEMBL30299377 | 0.85 | PDE3B (0.34) | ALDH1A1MAPTMAPK1LMNAGFER | |
| SCHEMBL29929506 | 0.83 | ALDH1A1 (0.33) | ALDH1A1MAPTMAPK1AXLLMNA | |
| SCHEMBL30090537 | 0.83 | TNIK (0.36) | GAA | |
| SCHEMBL30299369 | 0.83 | AXL (0.37) | ALDH1A1KDM4EMAPTMAPK1AXL | |
| SCHEMBL30299303 | 0.82 | CYP17A1 (0.36) | ALDH1A1MAPTMAPK1LMNAGFER | |
| SCHEMBL30090687 | 0.82 | AXL (0.38) | ALDH1A1KDM4EMAPTMAPK1AXL | |
| SCHEMBL29929683 | 0.81 | AXL (0.40) | ALDH1A1L3MBTL1AXLLMNA | |
| SCHEMBL30299368 | 0.81 | GAA (0.38) | ALDH1A1KDM4EMAPTPOLBMAPK1 | |
| SCHEMBL29928107 | 0.80 | MAPT (0.49) | ALDH1A1KDM4EMAPTNCF1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075303-A | Method of selecting patients treated with a combination of an AXL inhibitor and an immune checkpoint modulator | 卑尔根生物股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-115916344-A | AXL inhibitors for antiviral therapy | 卑尔根生物股份公司 | 2023-04-04 | — | — | CN | disclosed |