Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.53 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.49 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13211939 | 0.80 | SMN1; SMN2 (0.76) | SMN1; SMN2LMNAHPGDKLKB1EPHX2 | |
| SCHEMBL359196 | 0.80 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAHPGDKLKB1MAPK8 | |
| SCHEMBL12804153 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAHPGDMETKLKB1 | |
| SCHEMBL5079750 | 0.77 | CXCR4 (0.58) | SMN1; SMN2HPGDMETROCK2ROCK1 | |
| SCHEMBL10224605 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHPGDKLKB1MAPK8 | |
| SCHEMBL12804241 | 0.76 | ALDH1A1 (0.61) | SMN1; SMN2LMNAHPGDKLKB1NPC1 | |
| SCHEMBL1568038 | 0.75 | L3MBTL1 (0.70) | ROCK2ROCK1L3MBTL1MAPK1EPHX2 | |
| SCHEMBL28813692 | 0.75 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAHPGDKLKB1MMP13 | |
| SCHEMBL17546564 | 0.75 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAHPGDKLKB1CLK1 | |
| SCHEMBL3459872 | 0.75 | ERCC1 (0.65) | NPC1RAB9AEPHX2NR1H4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240294524-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2024-09-05 | — | — | US | disclosed |
| EP-3466929-B1 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | MILLENNIUM PHARM INC (US) | 2023-09-06 | — | — | EP | disclosed |
| US-20230113598-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | BIOGEN IDEC MA INC. | 2023-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240294524-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | PDK1, PDK2, PDK3 | SMN1; SMN2 3723/4885LMNA 3553/4885HPGD 616/4885 |
| US-20230113598-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | PDK1, PDK2, PDK3 | SMN1; SMN2 3723/4885LMNA 3553/4885HPGD 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.