SCHEMBL1085759

SCHEMBL1085759

Cn1cc(C(=O)Nc2ccccc2-c2ccc(F)c(F)c2F)c(C(F)(F)F)n1

nearest known ligand 0.55

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.55
POLB P06746 1/20 0.55
ATM Q13315 1/20 0.43
STING1 Q86WV6 1/20 0.43
GAA P10253 1/20 0.42
NTRK1 P04629 2/20 0.42
BACE1 P56817 3/20 0.42
BACE2 Q9Y5Z0 3/20 0.42
IRAK4 Q9NWZ3 6/20 0.42
WDR5 P61964 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL303186 0.89 LMNA (0.56) LMNAPOLBATMSTING1GAA
SCHEMBL4447678 0.87 LMNA (0.60) LMNAPOLBNTRK1BACE1BACE2
SCHEMBL675130 0.86 LMNA (0.51) LMNAPOLBATMSTING1GAA
SCHEMBL120547 0.86 LMNA (0.54) LMNAPOLBATMSTING1GAA
SCHEMBL29419095 0.86 LMNA (0.54) LMNAPOLBATMSTING1GAA
SCHEMBL1085546 0.86 LMNA (0.53) LMNAPOLBATMSTING1GAA
SCHEMBL29390999 0.86 LMNA (0.53) LMNAPOLBATMSTING1GAA
SCHEMBL4107917 0.85 LMNA (0.64) LMNAPOLBNTRK1BACE1BACE2
SCHEMBL19549033 0.85 LMNA (0.62) LMNAPOLBATMSTING1GAA
SCHEMBL29688585 0.85 LMNA (0.52) LMNAPOLBATMSTING1NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1856055-B1 PYRAZOLE CARBOXYLIC ACID ANILIDES, METHOD FOR THE PRODUCTION THEREOF AND AGENTS CONTAINING THEM FOR CONTROLLING PATHOGENIC FUNGI BASF SE (DE) 2014-10-01 EP claimed
US-8211828-B2 Fungicidal mixtures of 1-methylpyrazol-4-ylcarboxanilides and azolopyrimidinylamines BASF SE (DE) 2012-07-03 US claimed
US-8153819-B2 Fungicidal mixtures comprising substituted 1-methylpyrazol-4-ylcarboxanilides BASF SE (DE) 2012-04-10 US claimed
US-8008232-B2 Such as N-(3',4'-dichlorobiphenyl-2-yl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxamide; seeds BASF AKTIENGESELLSCHAFT (DE) 2011-08-30 US claimed
US-20090318291-A1 Fungicidal mixtures of 1-methylpyrazol-4-ylcarboxanilides and azolopyrimidinylamines BASF SE (DE) 2009-12-24 US claimed
US-20080293798-A1 Fungicidal Mixtures Comprising Substituted 1-Methylpyrazol-4-Ylcarboxanilides BASF AKTIENGELSELLSCHAFT (DE) 2008-11-27 US claimed
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi BASF AKITENGESELLSCHAFT (DE) 2008-06-26 US claimed
EP-3510869-A1 COMBINATIONS COMPRISING A FUNGICIDAL STRAIN AND AN ACTIVE COMPOUND Bayer Cropscience LP (US) 2019-07-17 EP disclosed
EP-3381289-A1 COMBINATIONS COMPRISING A FUNGICIDAL STRAIN AND AN ACTIVE COMPOUND Bayer Cropscience LP (US) 2018-10-03 EP disclosed
US-20170318816-A1 Combinations Comprising a Fungicidal Strain and an Active Compound BAYER CROPSCIENCE LP 2017-11-09 US disclosed
US-9480250-B2 Production of solid solutions of pesticides by short-term superheating and rapid drying BASF SE (DE) 2016-11-01 US disclosed
US-9392797-B2 Combinations comprising a fungicidal strain and an active compound BAYER CROPSCIENCE LP (US) 2016-07-19 US disclosed
US-20150264939-A1 Combinations Comprising a Fungicidal Strain and an Active Compound BAYER CROPSCIENCE LP 2015-09-24 US disclosed
EP-2319319-A1 Combinations comprising a fungicidal strain and at least one additional fungicide BASF SE (DE) 2011-05-11 EP disclosed
EP-2292098-A1 Combinations comprising a fungicidal strain and at least one additional fungicide BASF SE (DE) 2011-03-09 EP disclosed
EP-2292099-A1 Combinations comprising a fungicidal strain and at least one additional fungicide BASF SE (DE) 2011-03-09 EP disclosed
US-20100209410-A1 Combinations Comprising a Fungicidal Strain and an Active Compound BASF SE (DE) 2010-08-19 US disclosed
US-20100062940-A1 Production of Solid Solutions of Pesticides by Short-Term Superheating and Rapid Drying BASF SE (DE) 2010-03-11 US disclosed
US-20100035753-A1 Fungicidal Mixtures Comprising Substituted 1-methylpyrazol-4-ylcarboxanilides BASF SE (DE) 2010-02-11 US disclosed
US-20080293798-A1 Fungicidal Mixtures Comprising Substituted 1-Methylpyrazol-4-Ylcarboxanilides BASF AKTIENGELSELLSCHAFT (DE) 2008-11-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153707-A1 Pyrazolecarboxanilides, Process for Their Preparation and Compositions Comprising Them for Controlling Harmful Fungi CBR3, C1S, PYM1 LMNA 1073/4885POLB 2358/4885ATM 2473/4885
US-20100062940-A1 Production of Solid Solutions of Pesticides by Short-Term Superheating and Rapid Drying ACHE, CS, STOM LMNA 3755/4885POLB 3550/4885ATM 3335/4885
US-20090318291-A1 Fungicidal mixtures of 1-methylpyrazol-4-ylcarboxanilides and azolopyrimidinylamines ERG28, AZI2, CYP51A1 LMNA 1883/4885POLB 4234/4885ATM 1587/4885
US-20100209410-A1 Combinations Comprising a Fungicidal Strain and an Active Compound O60361, SPOUT1, FBL LMNA 1305/4885POLB 1177/4885ATM 3933/4885
US-20170318816-A1 Combinations Comprising a Fungicidal Strain and an Active Compound O60361, SPOUT1, FBL LMNA 1497/4885POLB 1623/4885ATM 3734/4885
US-20080293798-A1 Fungicidal Mixtures Comprising Substituted 1-Methylpyrazol-4-Ylcarboxanilides CBR3, CBR1, CTRL LMNA 1795/4885POLB 3941/4885ATM 3884/4885
US-20100035753-A1 Fungicidal Mixtures Comprising Substituted 1-methylpyrazol-4-ylcarboxanilides CBR3, CBR1, HCN2 LMNA 2198/4885POLB 4424/4885ATM 4260/4885
US-20150264939-A1 Combinations Comprising a Fungicidal Strain and an Active Compound O60361, SPOUT1, FBL LMNA 1317/4885POLB 1211/4885ATM 4095/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.