Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 3/20 | 0.43 |
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25702957 | 1.00 | GSK3B (0.46) | GSK3BHCAR3DEGS1NNMTEPHX2 | |
| SCHEMBL28653645 | 0.86 | GRIN2B (0.53) | GSK3BHCAR3DEGS1EPHX2HDAC1 | |
| SCHEMBL1203341 | 0.84 | PTK2 (0.54) | GSK3BHCAR3DEGS1NNMTEPHX2 | |
| SCHEMBL30320779 | 0.81 | DEGS1 (0.47) | HCAR3DEGS1NNMT | |
| SCHEMBL16865853 | 0.81 | HCAR3 (0.64) | GSK3BHCAR3NNMTPTPN1 | |
| SCHEMBL31661280 | 0.81 | HCAR3 (0.64) | GSK3BHCAR3NNMTPTPN1 | |
| SCHEMBL10033268 | 0.81 | HCAR3 (0.64) | HCAR3 | |
| SCHEMBL9772954 | 0.81 | ALDH1A1 (0.51) | GSK3BHCAR3DEGS1HDAC1 | |
| SCHEMBL16755148 | 0.80 | GCK (0.50) | HCAR3DEGS1 | |
| Bromide SCHEMBL16753536 | 0.80 | HCAR3 (0.62) | GSK3BHCAR3NNMTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183233-A1 | Bicyclic Pyridin-2-one and pyrimidin-4-one Derivatives Useful As a Factor XIa Inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-15 | — | — | US | disclosed |
| US-20230097157-A1 | Bicyclic Pyridin-2-one and pyrimidin-4-one Derivatives Useful As a Factor XIa Inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2023-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230097157-A1 | Bicyclic Pyridin-2-one and pyrimidin-4-one Derivatives Useful As a Factor XIa Inhibitors | KLKB1, F2, SERPINC1 | GSK3B 1699/4885HCAR3 2022/4885DEGS1 3066/4885 |
| US-20230183233-A1 | Bicyclic Pyridin-2-one and pyrimidin-4-one Derivatives Useful As a Factor XIa Inhibitors | KLKB1, F2, SERPINC1 | GSK3B 1699/4885HCAR3 2022/4885DEGS1 3066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.