Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 18/20 | 0.64 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | GCK | P35557 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30320779 | 0.86 | DEGS1 (0.47) | HCAR3 | |
| SCHEMBL2877186 | 0.84 | HCAR3 (0.57) | HCAR3HCAR2 | |
| SCHEMBL29651977 | 0.84 | HCAR3 (0.57) | HCAR3HCAR2 | |
| SCHEMBL7936803 | 0.83 | HCAR3 (0.55) | HCAR3HCAR2 | |
| SCHEMBL82675 | 0.82 | HCAR3 (0.68) | HCAR3HCAR2 | |
| SCHEMBL25702957 | 0.81 | GSK3B (0.46) | HCAR3 | |
| SCHEMBL30320778 | 0.81 | GSK3B (0.46) | HCAR3 | |
| SCHEMBL27874609 | 0.79 | HCAR3 (0.69) | HCAR3HCAR2 | |
| SCHEMBL17577318 | 0.79 | DEGS1 (0.60) | — | |
| SCHEMBL2056409 | 0.79 | RAB9A (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165520-A1 | PROCESS FOR THE SYNTHESIS OF PRODRUGS OF OPIOIDS | SHIRE LLC | 2012-06-28 | — | — | US | disclosed |
| US-20120165315-A1 | MEPTAZINOL CARBAMATE PRODRUG SALTS | JOSTENS, INC. | 2012-06-28 | — | — | US | disclosed |
| US-20110190267-A1 | PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE PHARMACEUTICALS, INC. (US) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165315-A1 | MEPTAZINOL CARBAMATE PRODRUG SALTS | MEP1A, MEP1B, CTSZ | HCAR3 439/4885HCAR2 647/4885NAPRT 218/4885 |
| US-20110190267-A1 | PRODRUGS OF OPIOIDS AND USES THEREOF | OPRK1, OPRL1, OPRM1 | HCAR3 70/4885HCAR2 96/4885NAPRT 477/4885 |
| US-20120165520-A1 | PROCESS FOR THE SYNTHESIS OF PRODRUGS OF OPIOIDS | OPRM1, OPRK1, OPRD1 | HCAR3 1145/4885HCAR2 971/4885NAPRT 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.