Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032849 | 0.95 | MAPK8 (0.40) | MAPK8ALDH1A1TDP1L3MBTL1P2RX7 | |
| Trifluoroacetic Acid SCHEMBL3023115 | 0.88 | CYP1A2 (0.37) | MAPK8ALDH1A1L3MBTL1P2RX7F3 | |
| Trifluoroacetic Acid SCHEMBL13560603 | 0.85 | CYP3A4 (0.42) | ALDH1A1P2RX7PTGES | |
| Trifluoroacetic Acid SCHEMBL3023663 | 0.85 | CYP3A4 (0.42) | P2RX7F3F2PKMMAPK1 | |
| SCHEMBL13982264 | 0.85 | POLB (0.37) | P2RX7PTGESPPARGPPARDPPARA | |
| Trifluoroacetic Acid SCHEMBL3035887 | 0.84 | CYP3A4 (0.41) | F3PKMMAPK1SMN1; SMN2PPARG | |
| Trifluoroacetic Acid SCHEMBL3017399 | 0.83 | CYP3A4 (0.40) | F3PKMMAPK1PTGESSMN1; SMN2 | |
| SCHEMBL3806168 | 0.83 | CYP3A4 (0.42) | PKMMAPK1PTGESSMN1; SMN2PPARG | |
| SCHEMBL13217563 | 0.82 | PKM (0.40) | MAPK8ALDH1A1TDP1L3MBTL1P2RX7 | |
| SCHEMBL13982436 | 0.82 | PTGES (0.38) | P2RX7F2PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | MAPK8 2972/4885ALDH1A1 348/4885TDP1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.