Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.49 |
| ▸ | PTGES | O14684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027901 | 0.87 | PIN1 (0.50) | ALDH1A1HSPB1PIN1PTGESMAPT | |
| SCHEMBL10422427 | 0.84 | ALDH1A1 (0.68) | ALDH1A1HSPB1PIN1PTGESMAPT | |
| SCHEMBL3033563 | 0.81 | TDP1 (0.44) | ALDH1A1HSPB1PIN1PTGESMAPT | |
| SCHEMBL13657593 | 0.80 | HSPB1 (0.46) | ALDH1A1HSPB1PIN1MAPTLMNA | |
| SCHEMBL3032884 | 0.77 | TDP1 (0.46) | ALDH1A1HSPB1PIN1PTGESMAPT | |
| SCHEMBL20222275 | 0.76 | ALDH1A1 (0.65) | ALDH1A1PIN1PTGESMAPTLMNA | |
| SCHEMBL21685849 | 0.76 | HSPB1 (0.74) | ALDH1A1HSPB1MAPTLMNAHTT | |
| SCHEMBL3023941 | 0.76 | PIN1 (0.41) | ALDH1A1HSPB1PIN1PTGESMAPT | |
| SCHEMBL28151906 | 0.75 | ALDH1A1 (0.48) | ALDH1A1PIN1PTGESMAPTLMNA | |
| SCHEMBL3023944 | 0.75 | PIN1 (0.40) | ALDH1A1HSPB1PIN1PTGESMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | ALDH1A1 348/4885HSPB1 4391/4885PIN1 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.