Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.55 |
| ▸ | GAA | P10253 | 9/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | RECQL | P46063 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | ALPG | P10696 | 1/20 | 0.51 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3040357 | 0.83 | KMT2A (0.60) | MAPTGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL1836733 | 0.83 | MAPT (0.51) | MAPTGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL10784807 | 0.80 | MAPT (0.47) | MAPTGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL6002938 | 0.75 | MAPT (0.43) | MAPTGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL3030170 | 0.74 | MAPT (0.55) | MAPTGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL6740798 | 0.74 | KMT2A (0.71) | MAPTGAAKMT2AALDH1A1MEN1 | |
| N-Benzoylaminorhodanine SCHEMBL8595198 | 0.72 | MAPT (0.74) | MAPTGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL28120186 | 0.71 | DDAH1 (0.53) | MAPTKMT2AALDH1A1MEN1CA12 | |
| SCHEMBL6793399 | 0.71 | ALDH1A1 (1.00) | MAPTGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL8356860 | 0.70 | MAPT (1.00) | MAPTGAAKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338465-B2 | Cyclic carboxylic acid rhodanine derivatives for the treatment and prevention of tuberculosis | CORNELL RESEARCH FOUNDATION, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100210577-A1 | CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS | CORNELL RESEARCH FOUNDATION, INC. | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210577-A1 | CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS | RARG, SDHA, RARS2 | MAPT 3973/4885GAA 162/4885KMT2A 3637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.