Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 6/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30391919 | 0.82 | TSHR (0.34) | CTSLCTSBCTSSALDH1A1TSHR | |
| SCHEMBL63048 | 0.79 | HPGD (0.36) | RNASEH1CTSLCTSBCTSSALDH1A1 | |
| SCHEMBL9942880 | 0.78 | HPGD (0.35) | CTSLCTSBCTSSALDH1A1KMT2A | |
| SCHEMBL63519 | 0.78 | OGFRL1 (0.41) | KMT2ATSHRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL52246 | 0.77 | HPGD (0.37) | CTSLCTSBCTSSKMT2AMEN1 | |
| SCHEMBL8266635 | 0.76 | KCNE1 (0.43) | RNASEH1CTSSALDH1A1KMT2AMEN1 | |
| SCHEMBL1117837 | 0.76 | CTSB (0.36) | CTSLCTSBCTSSPPIATSHR | |
| SCHEMBL9901321 | 0.75 | SMN1; SMN2 (0.35) | CTSLCTSBCTSSPPIAALDH1A1 | |
| SCHEMBL62151 | 0.74 | ADORA3 (0.37) | CTSLCTSBCTSS | |
| SCHEMBL9900673 | 0.74 | P2RX7 (0.34) | KMT2ALMNAMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136588-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2025-05-01 | — | — | US | disclosed |
| US-12172990-B2 | Modulators of TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2024-12-24 | — | — | US | disclosed |
| EP-3891145-B1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS INC (US) | 2023-04-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136588-A1 | MODULATORS OF TREX1 | TSNAX, TEAD1, TMX1 | RNASEH1 753/4885CTSL 905/4885CTSB 688/4885 |
| US-12172990-B2 | Modulators of TREX1 | CFTR, SLC10A1, CYP27A1 | RNASEH1 1364/4885CTSL 4375/4885CTSB 2403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.