SCHEMBL30395366

SCHEMBL30395366

FC(F)(F)C1(c2ccc(Br)cn2)CC1

nearest known ligand 0.34

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.34
ATM Q13315 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
KCNJ6 P48051 2/20 0.33
KCNJ5 P48544 2/20 0.33
KCNJ3 P48549 2/20 0.33
KDM4E B2RXH2 1/20 0.32
WDR5 P61964 1/20 0.32
TRPV1 Q8NER1 1/20 0.31
ADRA2A P08913 2/20 0.31
ADRA2B P18089 2/20 0.31
ADRA2C P18825 2/20 0.31
PLAU P00749 1/20 0.31
GBA1 P04062 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
FDPS P14324 1/20 0.30
BACE1 P56817 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25297918 1.00 ALDH1A1 (0.34) ALDH1A1ATML3MBTL1KCNJ6KCNJ5
SCHEMBL5737368 0.79 ADRA2A (0.33) ALDH1A1KDM4EADRA2AADRA2BADRA2C
SCHEMBL25261021 0.75
SCHEMBL30701650 0.73 KCNJ6 (0.37) ALDH1A1KCNJ6KCNJ5KCNJ3KDM4E
SCHEMBL17506392 0.73 KCNJ6 (0.37) ALDH1A1KCNJ6KCNJ5KCNJ3KDM4E
SCHEMBL30775689 0.73 KCNJ6 (0.32) KCNJ6KCNJ5KCNJ3
SCHEMBL30908333 0.73 P4HA1 (0.46) ALDH1A1L3MBTL1
SCHEMBL29990008 0.73 P4HA1 (0.46) ALDH1A1L3MBTL1
SCHEMBL25325457 0.72 KCNJ6 (0.34) KCNJ6KCNJ5KCNJ3
SCHEMBL31365792 0.72 KCNJ6 (0.34) KCNJ6KCNJ5KCNJ3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118355004-A Cyclopropyl- (heteroaryl) -substituted ethylsulfonyl-pyridine derivatives 勃林格殷格翰动物保健有限公司 2024-07-16 CN disclosed
EP-4208456-A1 HETEROCYCLIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2023-07-12 EP disclosed
CN-115989228-A Heterocyclic compounds 豪夫迈·罗氏有限公司 2023-04-18 CN disclosed