Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30409871 | 0.96 | KDM4E (0.41) | KDM4EMAPTALOX15SMN1; SMN2 | |
| Potassium Ion SCHEMBL9421284 | 0.75 | CA1 (0.37) | KDM4EMAPTALOX15SMN1; SMN2 | |
| SCHEMBL18980830 | 0.72 | KDM4E (0.38) | KDM4EMAPTALOX15SMN1; SMN2 | |
| SCHEMBL18983977 | 0.72 | KDM4E (0.38) | KDM4EMAPTALOX15SMN1; SMN2 | |
| Potassium Ion SCHEMBL11756064 | 0.72 | KDM4E (0.34) | KDM4EMAPTALOX15SMN1; SMN2 | |
| Nitrilotriacetic Acid SCHEMBL789295 | 0.71 | KDM4E (0.52) | KDM4EMAPTALOX15SMN1; SMN2 | |
| SCHEMBL718188 | 0.71 | CA1 (0.37) | KDM4EMAPTALOX15SMN1; SMN2 | |
| SCHEMBL5150621 | 0.71 | KDM4E (0.41) | KDM4EMAPTALOX15SMN1; SMN2 | |
| Potassium Ion SCHEMBL7649795 | 0.71 | KDM4E (0.41) | KDM4EMAPTALOX15SMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL6800515 | 0.69 | CA1 (0.35) | KDM4EMAPTALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116143842-A | Cyclometaliridium complex of oxidized iso-aporphine alkaloid and N-heterocyclic carbene, and synthetic method and application thereof | 广西师范大学 | 2023-05-23 | — | — | CN | disclosed |