Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.45 |
| ▸ | WEE1 | P30291 | 4/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.34 |
| ▸ | BAZ2A | Q9UIF9 | 3/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | RGS12 | O14924 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3046283 | 0.80 | MAPT (0.40) | CHEK1WEE1FTOGSK3BMEN1 | |
| SCHEMBL3048579 | 0.78 | CHEK1 (0.43) | CHEK1WEE1BRD4GSK3B | |
| SCHEMBL3037404 | 0.69 | TDP2 (0.37) | MEN1POLBMAPTKMT2AALDH1A1 | |
| SCHEMBL3040023 | 0.69 | CHEK1 (0.42) | CHEK1WEE1GSK3BMAPTALDH1A1 | |
| SCHEMBL1425210 | 0.69 | GAA (0.37) | CHEK1WEE1FTOGSK3BMEN1 | |
| SCHEMBL793085 | 0.68 | KDM4E (0.47) | CHEK1WEE1GSK3BMEN1POLB | |
| SCHEMBL3854593 | 0.67 | ALDH1A1 (0.50) | BAZ2BBAZ2ABRD4BRD9ALDH1A1 | |
| SCHEMBL1221964 | 0.66 | PDCD1 (0.54) | BAZ2BBAZ2ABRD4BRD9KMT2A | |
| SCHEMBL3044668 | 0.65 | WEE1 (0.46) | CHEK1WEE1GSK3BMEN1MAPT | |
| SCHEMBL3038080 | 0.65 | CA1 (0.39) | CHEK1WEE1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745641-B2 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1880993-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | NR4A1, NR5A2, PRMT8 | CHEK1 3306/4885WEE1 965/4885FTO 3580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.