Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.39 |
| ▸ | CCND1 | P24385 | 5/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.39 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.39 |
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | PRKACG | P22612 | 2/20 | 0.39 |
| ▸ | PRKACB | P22694 | 2/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3047003 | 0.76 | MAP3K9 (0.40) | CDK4CCND1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL3048654 | 0.70 | GSK3B (0.36) | CDK4CCND1CAMK2DCCNB2CDK1 | |
| SCHEMBL13290543 | 0.69 | ALDH1A1 (0.51) | MEN1KMT2AMAPT | |
| SCHEMBL18170525 | 0.64 | MAOA (0.45) | CDK4MEN1PRKD3PRKCGPRKCB | |
| SCHEMBL7429649 | 0.61 | THRB (0.55) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL3048668 | 0.61 | KDR (0.54) | PRKACAPRKACGPRKACBMEN1PRKD3 | |
| SCHEMBL11602909 | 0.61 | CDK4 (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL9832776 | 0.60 | WEE1 (0.75) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL9832547 | 0.59 | WEE1 (0.74) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Staurosporine Aglycon SCHEMBL29406635 | 0.58 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745641-B2 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-06-29 | — | — | US | disclosed |
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1880993-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | NR4A1, NR5A2, PRMT8 | CDK4 423/4885CCND1 1559/4885CCNE2 905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.