Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21894227 | 0.81 | TAAR1 (0.49) | NPSR1ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL11298255 | 0.75 | ALDH1A1 (0.53) | ALDH1A1MAPTALOX15HPGDKDM4E | |
| SCHEMBL2441467 | 0.74 | NOTUM (0.48) | ALDH1A1MAPTHPGDGAANPC1 | |
| SCHEMBL12956480 | 0.72 | NPC1 (0.42) | NPSR1ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL13366127 | 0.71 | PSMB5 (0.47) | ALDH1A1MAPTALOX15HPGDKDM4E | |
| SCHEMBL6123755 | 0.70 | ALDH1A1 (0.40) | ALDH1A1MAPTALOX15HPGDKDM4E | |
| SCHEMBL14255243 | 0.69 | MEN1 (0.47) | ALDH1A1HPGD | |
| SCHEMBL26516646 | 0.69 | THRB (0.35) | MAPTLMNA | |
| SCHEMBL5017049 | 0.67 | ALDH1A1 (0.40) | ALDH1A1MAPTALOX15KDM4EHSD17B10 | |
| SCHEMBL2441288 | 0.66 | TNKS2 (0.41) | ALDH1A1MAPTALOX15HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068794-A2 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2010-06-17 | — | — | WO | disclosed |