Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3057672 | 0.87 | MAPK1 (0.33) | HSD17B1HSD17B2S1PR1LMNA | |
| SCHEMBL3050887 | 0.86 | MTNR1A (0.40) | HTR6MEN1KMT2A | |
| SCHEMBL13139532 | 0.74 | MEN1 (0.47) | HTR6HSD17B1HSD17B2S1PR1MEN1 | |
| SCHEMBL3047557 | 0.74 | KMO (0.52) | HTR6HSD17B1HSD17B2S1PR1MEN1 | |
| SCHEMBL3055485 | 0.73 | BDKRB1 (0.38) | HTR6MEN1KMT2ALMNA | |
| SCHEMBL3049716 | 0.73 | PTGER3 (0.34) | MEN1KMT2A | |
| SCHEMBL3058830 | 0.69 | HSD17B1 (0.50) | HTR6HSD17B1HSD17B2S1PR1MEN1 | |
| SCHEMBL2866271 | 0.69 | OPRM1 (0.50) | MEN1KMT2ALMNA | |
| SCHEMBL3406256 | 0.69 | CD274 (0.45) | — | |
| SCHEMBL3061861 | 0.67 | MEN1 (0.48) | HTR6HSD17B1HSD17B2S1PR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | claimed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | claimed |
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | HTR6 103/4885HSD17B1 2880/4885HSD17B2 3507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.