Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 8/20 | 0.38 |
| ▸ | HTR6 | P50406 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065820 | 0.93 | BDKRB1 (0.39) | BDKRB1HTR6MEN1KMT2AF10 | |
| SCHEMBL3055517 | 0.86 | BDKRB1 (0.39) | BDKRB1MEN1KMT2AF10 | |
| SCHEMBL3056448 | 0.85 | MTNR1A (0.41) | BDKRB1HTR6MEN1KMT2AMAPK14 | |
| SCHEMBL3056437 | 0.80 | BDKRB1 (0.40) | BDKRB1MEN1KMT2AF10MAPT | |
| SCHEMBL3047557 | 0.76 | KMO (0.52) | HTR6MEN1KMT2A | |
| SCHEMBL4714168 | 0.75 | BDKRB1 (0.48) | BDKRB1MEN1KMT2AF10 | |
| SCHEMBL4711955 | 0.75 | BDKRB1 (0.49) | BDKRB1F10 | |
| SCHEMBL13139532 | 0.75 | MEN1 (0.47) | HTR6MEN1KMT2AMAPTTHRB | |
| SCHEMBL3060515 | 0.74 | BDKRB1 (0.48) | BDKRB1MAPK14F10MAPTLMNA | |
| SCHEMBL3049736 | 0.73 | HTR6 (0.41) | HTR6MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | claimed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | claimed |
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | BDKRB1 1/4885HTR6 103/4885MEN1 1256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.