Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 9/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.43 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | ROS1 | P08922 | 2/20 | 0.43 |
| ▸ | FER | P16591 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15175271 | 0.81 | CDK8 (0.43) | CDK8AXLGLO1PIK3CDPIK3CA | |
| SCHEMBL11029117 | 0.77 | CDK8 (0.52) | CDK8AXLGLO1PIK3CDPIK3CA | |
| SCHEMBL8099804 | 0.76 | RAB9A (0.49) | — | |
| SCHEMBL1659994 | 0.75 | KDM4E (0.52) | — | |
| SCHEMBL15176268 | 0.75 | PARP10 (0.39) | CDK8AXLGLO1PIK3CDPIK3CA | |
| SCHEMBL31365868 | 0.74 | KDM5B (0.50) | CLK4PIM1MAPK1GSK3BHIPK2 | |
| SCHEMBL28958139 | 0.74 | KDM5B (0.50) | CLK4PIM1MAPK1GSK3BHIPK2 | |
| SCHEMBL1834856 | 0.72 | ADORA3 (0.47) | ROCK2MAP4K4CLK4PIM1GSK3B | |
| SCHEMBL8100175 | 0.71 | GRM5 (0.55) | MAP4K4CSNK1DCLK2BLKCSNK2A1 | |
| SCHEMBL8105559 | 0.71 | RAB9A (0.54) | METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3644996-B1 | METHODS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2023-07-26 | — | — | EP | claimed |