Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.69 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.55 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LAP3 | P28838 | 3/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Leucine SCHEMBL3416402 | 0.89 | SLC7A5 (0.64) | SLC7A5SLC1A3SLC1A2ALDH1A1LAP3 | |
| SCHEMBL8741147 | 0.89 | SLC7A5 (0.53) | SLC7A5SLC1A3SLC1A2ALDH1A1LAP3 | |
| Alanine SCHEMBL9439316 | 0.88 | ALDH1A1 (0.53) | SLC7A5SLC1A3SLC1A2ALDH1A1LAP3 | |
| D-Alanine SCHEMBL3421250 | 0.88 | ALDH1A1 (0.53) | SLC7A5SLC1A3SLC1A2ALDH1A1LAP3 | |
| Alanine SCHEMBL516189 | 0.88 | ALDH1A1 (0.53) | SLC7A5SLC1A3SLC1A2ALDH1A1LAP3 | |
| SCHEMBL93452 | 0.88 | ALDH1A1 (0.61) | SLC7A5ALDH1A1LAP3MEN1LMNA | |
| SCHEMBL93453 | 0.88 | ALDH1A1 (0.61) | SLC7A5ALDH1A1LAP3MEN1LMNA | |
| SCHEMBL93451 | 0.88 | ALDH1A1 (0.61) | SLC7A5ALDH1A1LAP3MEN1LMNA | |
| Ammonia Solution, Strong SCHEMBL4650725 | 0.86 | ALDH1A1 (0.59) | SLC7A5ALDH1A1LAP3MEN1LMNA | |
| Hydrochloric Acid SCHEMBL19924628 | 0.86 | ALDH1A1 (0.59) | SLC7A5ALDH1A1LAP3MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737114-B2 | Didemnin analogs and fragments and methods of making and using them | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-15 | — | — | US | claimed |
| US-20070111928-A1 | Didemnin analogs and fragments and methods of making and using them | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-05-17 | — | — | US | claimed |
| US-7122519-B2 | Didemnin analogs and fragments and methods of making and using them | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-10-17 | — | — | US | claimed |
| US-20030104991-A1 | Didemnin analogs and fragments and methods of making and using them | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2003-06-05 | — | — | US | claimed |
| US-6509315-B1 | Useful for, among other things, inhibiting protein synthesis, cell growth, cell proliferation, and tumorigenesis | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2003-01-21 | — | — | US | claimed |
| US-20150315241-A1 | Antibiotic Peptides | AMP-THERAPEUTICS GMBH (DE) | 2015-11-05 | — | — | US | disclosed |
| US-9060513-B2 | Antibiotic peptides | AMP-THERAPEUTICS GMBH (DE) | 2015-06-23 | — | — | US | disclosed |
| US-20100222268-A1 | ANTIBIOTIC PEPTIDES | AMP-THERAPEUTICS GMBH & CO. KG | 2010-09-02 | — | — | US | disclosed |
| US-7737114-B2 | Didemnin analogs and fragments and methods of making and using them | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-15 | — | — | US | disclosed |
| US-20070111928-A1 | Didemnin analogs and fragments and methods of making and using them | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-05-17 | — | — | US | disclosed |
| US-7122519-B2 | Didemnin analogs and fragments and methods of making and using them | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-10-17 | — | — | US | disclosed |
| US-6509315-B1 | Useful for, among other things, inhibiting protein synthesis, cell growth, cell proliferation, and tumorigenesis | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2003-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030104991-A1 | Didemnin analogs and fragments and methods of making and using them | BAD, MDN1, HDGF | SLC7A5 4265/4885SLC1A3 4678/4885SLC1A2 4820/4885 |
| US-20070111928-A1 | Didemnin analogs and fragments and methods of making and using them | BAD, MDN1, HDGF | SLC7A5 4265/4885SLC1A3 4678/4885SLC1A2 4820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.