Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA known ✓ | P42336 | 3/20 | 0.41 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | MLNR known ✓ | O43193 | 2/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 11/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL10180525 | 1.00 | PIK3CA (0.41) | PIK3CAPRKAA2HRH3MLNRSTAT3 | |
| Fumaric Acid SCHEMBL3067431 | 0.94 | PIK3CA (0.41) | PIK3CAPRKAA2HRH3MLNRSTAT3 | |
| Maleic Acid SCHEMBL3067428 | 0.94 | PIK3CA (0.41) | PIK3CAPRKAA2HRH3MLNRSTAT3 | |
| Maleic Acid SCHEMBL3057423 | 0.91 | PKM (0.40) | PIK3CAPRKAA2HRH3MLNRSTAT3 | |
| Fumaric Acid SCHEMBL3057426 | 0.91 | PKM (0.40) | PIK3CAPRKAA2HRH3MLNRSTAT3 | |
| Fumaric Acid SCHEMBL3054567 | 0.90 | STAT3 (0.45) | PIK3CAPRKAA2STAT3SCN9A | |
| Maleic Acid SCHEMBL3054564 | 0.90 | STAT3 (0.45) | PIK3CAPRKAA2STAT3SCN9A | |
| Fumaric Acid SCHEMBL3069662 | 0.89 | STAT3 (0.45) | PIK3CAPRKAA2HRH3STAT3 | |
| Maleic Acid SCHEMBL3069658 | 0.89 | STAT3 (0.45) | PIK3CAPRKAA2HRH3STAT3 | |
| Maleic Acid SCHEMBL3062041 | 0.89 | STAT3 (0.42) | PIK3CAPRKAA2MLNRSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8551999-B2 | Heterocyclic compound and pharmaceutical composition thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2207773-B1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMA CO LTD (JP) | 2012-07-11 | — | — | EP | disclosed |
| US-20100261720-A1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261720-A1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | COL1A1, COL2A1, COL14A1 | PIK3CA 3582/4885HRH3 19/4885MLNR 3041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.