Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980773 | 0.73 | ALDH1A1 (0.57) | ALDH1A1MAPTHSD17B10KDM4CCACNA1B | |
| SCHEMBL1639996 | 0.72 | ALDH1A1 (0.42) | MGLLGRK5TYRO3DYRK1BATM | |
| SCHEMBL17717930 | 0.72 | ALDH1A1 (0.53) | MGLLGRK5TYRO3DYRK1BATM | |
| SCHEMBL17408808 | 0.70 | CACNA1B (0.42) | MGLLGRK5TYRO3DYRK1BALDH1A1 | |
| SCHEMBL472396 | 0.69 | ALDH1A1 (0.56) | ALDH1A1MAPTHSD17B10KDM4CMEN1 | |
| SCHEMBL17717928 | 0.69 | ALDH1A1 (0.50) | GRK5TYRO3DYRK1BALDH1A1MAPT | |
| SCHEMBL17717951 | 0.69 | ALDH1A1 (0.60) | ALDH1A1MAPTHSD17B10KDM4CMEN1 | |
| SCHEMBL11379242 | 0.69 | CACNA1B (0.45) | ALDH1A1MAPTHSD17B10KDM4CITGA4 | |
| SCHEMBL17717943 | 0.68 | MAPT (0.58) | ATMALDH1A1MAPTHSD17B10KDM4C | |
| SCHEMBL17358726 | 0.67 | KMT2A (0.46) | ALDH1A1MAPTHSD17B10KDM4CITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4574821-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | Terns, Inc. (US) | 2025-06-25 | — | — | EP | disclosed |
| US-20250179053-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2025-06-05 | — | — | US | disclosed |
| US-20250179054-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2025-06-05 | — | — | US | disclosed |
| EP-4529954-A2 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | Terns, Inc. (US) | 2025-04-02 | — | — | EP | disclosed |
| US-20230278988-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | TERNS PHARMACEUTICALS, INC. | 2023-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250179054-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | MGLL 3828/4885GRK5 103/4885TYRO3 79/4885 |
| US-20250179053-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | MGLL 3828/4885GRK5 103/4885TYRO3 79/4885 |
| US-20230278988-A1 | THRB RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF | THRB, THRA, TRHR | MGLL 3828/4885GRK5 103/4885TYRO3 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.