Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.40 |
| ▸ | FABP7 | O15540 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678800 | 0.86 | KMT2A (0.41) | KMT2AKDM4EALDH1A1GAAFABP5 | |
| SCHEMBL7764 | 0.82 | CA1 (0.53) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL1934963 | 0.82 | AKR1B1 (0.41) | KMT2AALDH1A1GAAFABP5FABP7 | |
| SCHEMBL29633623 | 0.80 | TTR (0.49) | TTRPTPRCKMT2AKDM4EMEN1 | |
| SCHEMBL3355711 | 0.80 | TTR (0.49) | TTRPTPRCKMT2AKDM4EMEN1 | |
| SCHEMBL18055683 | 0.79 | CA1 (0.42) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL1934919 | 0.78 | ALDH1A1 (0.43) | KMT2AKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL8007580 | 0.78 | EPHX2 (0.32) | KMT2AFABP5FABP7HTR7HTR2B | |
| SCHEMBL135438 | 0.77 | CA1 (0.44) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL28678862 | 0.77 | CA1 (0.40) | KMT2AFABP5FABP7CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937040-B2 | Antibiotic compositions for the treatment of gram negative infections | BIOSOURCE PHARM, INC. (US) | 2015-01-20 | — | — | US | disclosed |
| US-8906866-B2 | Antibiotic compositions for the treatment of gram negative infections | BIOSOURCE PHARM, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140073559-A1 | Antibiotic Compositions for the Treatment of Gram Negative Infections | CUBIST PHARMACEUTICALS, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-20130345121-A1 | Antibiotic Compositions For The Treatment of Gram Negative Infections | BIOSOURCE PHARM, INC. (US) | 2013-12-26 | — | — | US | disclosed |
| US-8415307-B1 | Antibiotic compositions for the treatment of gram negative infections | BIOSOURCE PHARM, INC. (US) | 2013-04-09 | — | — | US | disclosed |
| US-8343912-B2 | Antibiotic compositions for the treatment of gram negative infections | BIOSOURCE PHARM, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| WO-2010075416-A1 | ANTIBIOTIC COMPOSITIONS FOR THE TREATMENT OF GRAM NEGATIVE INFECTIONS | BIOSOURCE PHARM, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100160215-A1 | ANTIBIOTIC COMPOSITIONS FOR THE TREATMENT OF GRAM NEGATIVE INFECTIONS | BIOSOURCE PHARM, INC. | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345121-A1 | Antibiotic Compositions For The Treatment of Gram Negative Infections | PSMB7, MDN1, PSMB6 | TTR 2527/4885PTPRC 3953/4885KMT2A 3996/4885 |
| US-20140073559-A1 | Antibiotic Compositions for the Treatment of Gram Negative Infections | RPN2, NRDC, RPN1 | TTR 3057/4885PTPRC 2972/4885KMT2A 2991/4885 |
| US-20100160215-A1 | ANTIBIOTIC COMPOSITIONS FOR THE TREATMENT OF GRAM NEGATIVE INFECTIONS | PSMB7, IL17A, IL1B | TTR 3633/4885PTPRC 3511/4885KMT2A 4393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.