Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 5/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771649 | 0.83 | GABRA1 (0.43) | TSHRGABRA1GABRB2 | |
| SCHEMBL9463585 | 0.80 | P2RX7 (0.37) | TSHRP2RX7GABRA1GABRB2 | |
| SCHEMBL8666074 | 0.79 | TSHR (0.34) | TSHRIDO1GABRA1GABRB2ESR1 | |
| SCHEMBL11816146 | 0.78 | NLRP3 (0.47) | — | |
| SCHEMBL9571993 | 0.78 | TSHR (0.53) | TSHRGABRA1GABRB2 | |
| SCHEMBL11265054 | 0.77 | P2RX7 (0.39) | TSHRP2RX7GABRA1GABRB2 | |
| SCHEMBL9492902 | 0.77 | GABRA1 (0.48) | TSHRP2RX7GABRA1GABRB2 | |
| SCHEMBL11262186 | 0.77 | GABRA1 (0.43) | TSHRP2RX7GABRA1GABRB2 | |
| SCHEMBL31158055 | 0.77 | P2RX7 (0.39) | TSHRP2RX7GABRA1GABRB2 | |
| SCHEMBL13145477 | 0.75 | TSHR (0.56) | TSHRIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157388-A | Carbocyclic amide derivative and application thereof in medicine | 四川海思科制药有限公司 | 2023-05-23 | — | — | CN | disclosed |
| US-20230130894-A1 | COMPOUND, LIQUID CRYSTAL COMPOSITION, CURED SUBSTANCE, AND FILM | FUJIFILM CORPORATION (JP) | 2023-04-27 | — | — | US | disclosed |
| EP-4144820-A1 | COMPOUND, LIQUID CRYSTAL COMPOSITION, CURED PRODUCT AND FILM | FUJIFILM Corporation (JP) | 2023-03-08 | — | — | EP | disclosed |
| CN-115461320-A | Compound, liquid crystal composition, cured product and film | 富士胶片株式会社 | 2022-12-09 | — | — | CN | disclosed |
| CN-107438599-B | Targeted Notch pathway inhibitors | 豪夫迈·罗氏有限公司 | 2021-12-10 | — | — | CN | disclosed |
| CN-112449638-A | Antibacterial compounds | 英菲克斯治疗有限公司 | 2021-03-05 | — | — | CN | disclosed |
| US-7789610-B2 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | CEPHALON, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20100222340-A1 | SUBSTITUTED PYRIDO [1,2-a] ISOQUINOLINE DERIVATIVES | BOEHRINGER MARKUS | 2010-09-02 | — | — | US | disclosed |
| EP-1851216-A2 | SUBSTITUTED BENZOQUINOLIZINES AS DPP-IV INHIBITORS FOR THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-11-07 | — | — | EP | disclosed |
| EP-1126855-B1 | USE OF FUSED PYRROLOCARBAZOLES FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON INC (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006058628-A2 | SUBSTITUTED BENZOQUINOLIZINES AS DPP-IV INHIBITORS FOR THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-06-08 | — | — | WO | disclosed |
| US-20060116393-A1 | Substituted pyrido [2,1-a] isoquinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-01 | — | — | US | disclosed |
| EP-1126855-A4 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON INC (US) | 2004-05-19 | — | — | EP | disclosed |
| US-6448283-B1 | FUSED PYRROLOCARBAZOLES; HEARING LOSS AND LOSS OF THE SENSE OF BALANCE | CEPHALON, INC. | 2002-09-10 | — | — | US | disclosed |
| US-20020115706-A1 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | CEPHALON, INC. | 2002-08-22 | — | — | US | disclosed |
| EP-1126855-A1 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON, INC. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000018407-A9 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON INC (US) | 2000-09-21 | — | — | WO | disclosed |
| WO-2000018407-A1 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON, INC. (US) | 2000-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116393-A1 | Substituted pyrido [2,1-a] isoquinoline derivatives | DPP4, DPP7, DPP3 | TSHR 959/4885P2RX7 285/4885IDO1 171/4885 |
| US-20100222340-A1 | SUBSTITUTED PYRIDO [1,2-a] ISOQUINOLINE DERIVATIVES | DPP4, DPP7, DPP3 | TSHR 935/4885P2RX7 291/4885IDO1 178/4885 |
| US-20020115706-A1 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | GJB2, GAP43, MYOC | TSHR 4421/4885P2RX7 2995/4885IDO1 4467/4885 |
| US-20230130894-A1 | COMPOUND, LIQUID CRYSTAL COMPOSITION, CURED SUBSTANCE, AND FILM | FLNB, MAOB, PYCARD | TSHR 3825/4885P2RX7 1997/4885IDO1 2918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.