Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 12/20 | 0.60 |
| ▸ | HTR2A | P28223 | 5/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14157333 | 0.98 | TAAR1 (0.58) | TAAR1HTR2AHRH1CYP2A6SMN1; SMN2 | |
| SCHEMBL29488434 | 0.87 | ADRA2B (0.44) | TAAR1 | |
| SCHEMBL224549 | 0.87 | TAAR1 (0.70) | TAAR1HTR2AHRH1CYP2A6SMN1; SMN2 | |
| SCHEMBL142479 | 0.87 | ADRA2B (0.44) | TAAR1 | |
| SCHEMBL10662902 | 0.86 | TAAR1 (0.45) | TAAR1HTR2A | |
| SCHEMBL3067170 | 0.86 | TAAR1 (0.56) | TAAR1HTR2AHRH1CYP3A4CYP2D6 | |
| SCHEMBL2907330 | 0.85 | TAAR1 (0.60) | TAAR1HTR2AHRH1CYP2A6SMN1; SMN2 | |
| SCHEMBL283610 | 0.85 | PNMT (0.46) | TAAR1HTR2A | |
| Benzene SCHEMBL11786397 | 0.84 | KDM4E (0.44) | TAAR1HTR2A | |
| SCHEMBL9839840 | 0.84 | ADRA2B (0.43) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3628374-A2 | BCL-3 INHIBITORS | University College Cardiff Consultants Limited (GB) | 2020-04-01 | — | — | EP | disclosed |
| US-8394979-B2 | Process for preparing cycloplatinated platinum complexes, platinum complexes prepared by this process and the use thereof | RHEINISCHE-WESTFALISCHE TECHNISCHE HOCHSCHULE AACHEN (DE) | 2013-03-12 | — | — | US | disclosed |
| US-20100267977-A1 | METHOD FOR PRODUCING CYCLOPLATINIZED PLATINUM COMPLEXES, PLATINUM COMPLEXES PRODUCED BY SAID METHOD, AND THE USE THEREOF | RHEINISCHE-WESTFALISCHE TECHNISCHE HOCHSCHULE AACHEN (DE) | 2010-10-21 | — | — | US | disclosed |
| EP-2130820-A1 | Antipruritics | SHIONOGI & CO., LTD. (JP) | 2009-12-09 | — | — | EP | disclosed |
| EP-1477186-B1 | ANTIPRURITICS | SHIONOGI & CO (JP) | 2009-11-11 | — | — | EP | disclosed |
| US-20080312292-A1 | Antipruritics | YASUI KIYOSHI | 2008-12-18 | — | — | US | disclosed |
| US-7420053-B2 | 2-imino-1,3-thiazine derivatives | SHIONOGI & CO., LTD. (JP) | 2008-09-02 | — | — | US | disclosed |
| EP-1375489-B1 | MEDICINAL COMPOSITION CONTAINING 1,3-THIAZINE DERIVATIVE | SHIONOGI & CO (JP) | 2008-08-20 | — | — | EP | disclosed |
| EP-1219612-B1 | 2-IMINO-1,3-THIAZINE DERIVATIVES | SHIONOGI & CO (JP) | 2008-04-23 | — | — | EP | disclosed |
| US-20070088020-A1 | 2-imino-1,3-thiazine derivatives | HANASAKI KOJI | 2007-04-19 | — | — | US | disclosed |
| US-6506937-B2 | Used as antiarrhythmics | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-01-14 | — | — | US | disclosed |
| EP-1219612-A1 | 2-IMINO-1,3-THIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-20020058838-A1 | Substituted benzenesulfonylureas and -thioureas-processes for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT | 2002-05-16 | — | — | US | disclosed |
| US-6335467-B1 | INTERMEDIATES FOR ANTIARRHYTHMIA AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2002-01-01 | — | — | US | disclosed |
| US-6090981-A | ANTIARRHYTHMICS. | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-07-18 | — | — | US | disclosed |
| US-5776980-A | Substituted benzenesulfonylureas and -thioureas-process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5698596-A | ANTIARRHYTHMIA AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-16 | — | — | US | disclosed |
| EP-0612724-B1 | Substituted benzenesulfonylureas and -thioureas, process for their preparation and their use as pharmaceuticals | HOECHST AG (DE) | 1996-12-27 | — | — | EP | disclosed |
| US-5574069-A | ANTIARRHYTHMIA | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-11-12 | — | — | US | disclosed |
| EP-0612724-A1 | Substituted benzenesulfonylureas and -thioureas, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058838-A1 | Substituted benzenesulfonylureas and -thioureas-processes for their preparation and their use as pharmaceuticals | KCNH1, KCNH2, KCNH3 | TAAR1 442/4885HTR2A 1329/4885HRH1 70/4885 |
| US-20080312292-A1 | Antipruritics | CNR1, CNR2, OPRL1 | TAAR1 203/4885HTR2A 228/4885HRH1 8/4885 |
| US-20100267977-A1 | METHOD FOR PRODUCING CYCLOPLATINIZED PLATINUM COMPLEXES, PLATINUM COMPLEXES PRODUCED BY SAID METHOD, AND THE USE THEREOF | THPO, MCL1, PPOX | TAAR1 4519/4885HTR2A 4718/4885HRH1 3560/4885 |
| US-20070088020-A1 | 2-imino-1,3-thiazine derivatives | CNR2, CNR1, HTR2C | TAAR1 99/4885HTR2A 8/4885HRH1 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.