Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 5/20 | 0.68 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.68 |
| ▸ | TTR | P02766 | 3/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | JUN | P05412 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20914971 | 1.00 | AKR1B10 (0.68) | AKR1B10AKR1B1TTRALOX5ATM | |
| SCHEMBL30449408 | 0.93 | AKR1B10 (0.69) | AKR1B10AKR1B1TTRALOX5ATM | |
| SCHEMBL20914994 | 0.93 | AKR1B10 (0.69) | AKR1B10AKR1B1TTRALOX5ATM | |
| SCHEMBL14113938 | 0.81 | TTR (1.00) | AKR1B10AKR1B1TTRALOX5NFKB1 | |
| SCHEMBL20914964 | 0.80 | ALOX5 (0.73) | AKR1B10AKR1B1TTRALOX5NFKB1 | |
| SCHEMBL15164734 | 0.80 | JUN (0.56) | AKR1B10AKR1B1ATMJUNNFKB1 | |
| SCHEMBL20914978 | 0.80 | AKR1B10 (0.66) | AKR1B10AKR1B1TTRALOX5KDM4E | |
| SCHEMBL30610039 | 0.80 | AKR1B10 (0.66) | AKR1B10AKR1B1TTRALOX5KDM4E | |
| SCHEMBL20914958 | 0.79 | TTR (1.00) | AKR1B10AKR1B1TTRALOX5NFKB1 | |
| SCHEMBL22423058 | 0.78 | ALOX5 (0.75) | AKR1B10AKR1B1TTRALOX5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425441-A9 | MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY | ICOSA PHARMA INC. (CA) | 2024-12-26 | — | — | US | disclosed |
| US-20230391711-A1 | MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY | UNIV DE MONCTON (CA) | 2023-12-07 | — | — | US | disclosed |
| US-11760715-B2 | Modulators of lipoxygenase and cyclooxygenase enzyme activity | UNIVERSITÉ DE MONCTON (CA) | 2023-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240425441-A9 | MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY | ALOX12, ALOX15B, ALOX5 | AKR1B10 392/4885AKR1B1 182/4885TTR 3270/4885 |
| US-11760715-B2 | Modulators of lipoxygenase and cyclooxygenase enzyme activity | ALOX12, ALOX15B, ALOX5 | AKR1B10 392/4885AKR1B1 182/4885TTR 3270/4885 |
| US-20230391711-A1 | MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY | ALOX12, ALOX15B, ALOX5 | AKR1B10 392/4885AKR1B1 182/4885TTR 3270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.