Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 5/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.62 |
| ▸ | TTR | P02766 | 3/20 | 0.62 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20914978 | 1.00 | AKR1B10 (0.66) | AKR1B10AKR1B1ALOX5TTRNFE2L2 | |
| SCHEMBL20915000 | 0.93 | AKR1B10 (0.67) | AKR1B10AKR1B1ALOX5TTRNFE2L2 | |
| SCHEMBL30449449 | 0.93 | AKR1B10 (0.67) | AKR1B10AKR1B1ALOX5TTRNFE2L2 | |
| SCHEMBL8157283 | 0.82 | NFE2L2 (0.59) | ALOX5NFE2L2L3MBTL1TRPM8KDM4E | |
| SCHEMBL6926347 | 0.82 | NFE2L2 (0.59) | AKR1B10AKR1B1ALOX5NFE2L2L3MBTL1 | |
| SCHEMBL4592982 | 0.82 | NFE2L2 (0.69) | ALOX5NFE2L2L3MBTL1TRPM8KDM4E | |
| SCHEMBL20914992 | 0.81 | ALOX5 (0.83) | AKR1B10AKR1B1ALOX5TTRKDM4E | |
| SCHEMBL26322703 | 0.81 | AKR1B10 (0.61) | AKR1B10AKR1B1ALOX5TTRKDM4E | |
| SCHEMBL2226672 | 0.81 | NFE2L2 (0.60) | ALOX5NFE2L2L3MBTL1TRPM8KDM4E | |
| SCHEMBL20914971 | 0.80 | AKR1B10 (0.68) | AKR1B10AKR1B1ALOX5TTRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425441-A9 | MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY | ICOSA PHARMA INC. (CA) | 2024-12-26 | — | — | US | disclosed |
| US-20230391711-A1 | MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY | UNIV DE MONCTON (CA) | 2023-12-07 | — | — | US | disclosed |
| US-11760715-B2 | Modulators of lipoxygenase and cyclooxygenase enzyme activity | UNIVERSITÉ DE MONCTON (CA) | 2023-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240425441-A9 | MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY | ALOX12, ALOX15B, ALOX5 | AKR1B10 392/4885AKR1B1 182/4885ALOX5 3/4885 |
| US-11760715-B2 | Modulators of lipoxygenase and cyclooxygenase enzyme activity | ALOX12, ALOX15B, ALOX5 | AKR1B10 392/4885AKR1B1 182/4885ALOX5 3/4885 |
| US-20230391711-A1 | MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY | ALOX12, ALOX15B, ALOX5 | AKR1B10 392/4885AKR1B1 182/4885ALOX5 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.